13048-95-8

Basic information

• Product Name: N(4), O(2')-dimethylcytidine
• Synonyms: N(4), O(2')-dimethylcytidine;N4-Methyl-2'-O-Methyl-cytidine;N,2'-O-Dimethylcytidine
• CAS NO: 13048-95-8
• Molecular Formula: C11H17N3O5
• Molecular Weight: 271.26978
• Mol File: 13048-95-8.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 475.4°Cat760mmHg
• Flash Point: 241.3°C
• Appearance: /
• Density: 1.54g/cm³
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility: Aqueous Base (Slightly), DMSO (Slightly), Water (Slightly)
• PKA: 13.37±0.70(Predicted)
• CAS DataBase Reference: N(4), O(2')-dimethylcytidine(CAS DataBase Reference)
• NIST Chemistry Reference: N(4), O(2')-dimethylcytidine(13048-95-8)
• EPA Substance Registry System: N(4), O(2')-dimethylcytidine(13048-95-8)

Safety Data

• Hazardous Substances Data: 13048-95-8(Hazardous Substances Data)

Usage

Description

N(4), O(2')-dimethylcytidine is a modified form of the nucleoside cytidine, which is found in RNA molecules. It has two methyl groups attached to the nitrogen atom at position 4 and the oxygen atom at position 2' of the ribose sugar. This modification is involved in the regulation of gene expression and RNA processing, playing a crucial role in the modification of RNA structure and function.

Uses

Used in Biomedical Research:
N(4), O(2')-dimethylcytidine is used as a potential biomarker for certain diseases, making it an area of interest in biomedical research. Its presence in various organisms, including bacteria, plants, and animals, highlights its significance in understanding the molecular mechanisms underlying various biological processes and disease states.
Used in RNA Structure and Function Studies:
N(4), O(2')-dimethylcytidine is used as a key component in the study of RNA structure and function. Its role in the regulation of gene expression and RNA processing makes it an important molecule for researchers to investigate the intricate ways in which RNA molecules are regulated and how they contribute to cellular function and disease.
Used in Drug Development:
Given its involvement in gene expression and RNA processing, N(4), O(2')-dimethylcytidine may also be used as a target for drug development. Modulating the levels or activity of this modified nucleoside could potentially lead to the development of new therapeutics for diseases where RNA dysregulation plays a role.

Upstream product

• 1613530-40-7 C₂₃H₄₅N₃O₅Si₂ 
• 1428902-86-6 C₂₄H₄₃N₅O₅Si₂ 
• 367511-37-3 C₂₂H₄₂N₂O₆Si₂ 
• 2140-76-3 2'-O-methyluridine 
• 1085342-83-1 3',5'-di-O-acetyl-N⁴,2'-O-dimethylcytidine 
• 415903-48-9 3',5'-O-(1,1,3,3-tetraisopropyl-1,3-disiloxanediyl)-2'-O-(trimethylsilyl)uridine 
• 110567-19-6 1-(3',5'-O-1,1,3,3-tetraisopropyl-1,3-disilyl)-β-D-ribofuranosyl-2'-O-methyl-4-(2-nitrophenyl)-2-pyrimidinone 
• 108782-90-7 1-(3',5'-O-1,1,3,3-tetraisopropyl-1,3-disilyl)-β-D-ribofuranosyl-4-(2-nitrophenyl)-2-pyrimidinone 
• 110588-51-7 4-N-methyl-3',5'-(1,1,3,3-tetraisopropyl-1,3-disilyl)-2'-O-methylcytidine 
• 17287-03-5 trimethylsulphonium hydroxide 
• 2140-72-9 2'-O-methylcytidine 
• 69304-38-7 3',5'-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine 
• 58-96-8 uridine 

Relevant articles and documents

Synthesis and solution conformation studies of the modified nucleoside N4,2′-O-dimethylcytidine (m4Cm) and its analogues

The dimethylated ribosomal nucleoside m4Cm and its monomethylated analogues Cm and m4C were synthesized. The conformations (syn vs anti) of the three modified nucleosides and cytidine were determined by CD and 1D NOE difference spectroscopy. The ribose sugar puckers were determined by the use of proton coupling constants. The position of modification (e.g., O vs N methylation) was found to have an effect on the sugar pucker of cytidine.

ALTERNATIVE NUCLEIC ACID MOLECULES AND USES THEREOF

The present disclosure provides alternative nucleosides, nucleotides, and nucleic acids, and methods of using them.

MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF

The present disclosure provides modified nucleosides, nucleotides, and nucleic acids, and methods of using them.