13048-95-8

Usage

Uses

Used in Biomedical Research:
N(4), O(2')-dimethylcytidine is used as a potential biomarker for certain diseases, making it an area of interest in biomedical research. Its presence in various organisms, including bacteria, plants, and animals, highlights its significance in understanding the molecular mechanisms underlying various biological processes and disease states.
Used in RNA Structure and Function Studies:
N(4), O(2')-dimethylcytidine is used as a key component in the study of RNA structure and function. Its role in the regulation of gene expression and RNA processing makes it an important molecule for researchers to investigate the intricate ways in which RNA molecules are regulated and how they contribute to cellular function and disease.
Used in Drug Development:
Given its involvement in gene expression and RNA processing, N(4), O(2')-dimethylcytidine may also be used as a target for drug development. Modulating the levels or activity of this modified nucleoside could potentially lead to the development of new therapeutics for diseases where RNA dysregulation plays a role.

Upstream product

• 17287-03-5 trimethylsulphonium hydroxide 
• 2140-72-9 2'-O-methylcytidine 
• 110588-51-7 4-N-methyl-3',5'-(1,1,3,3-tetraisopropyl-1,3-disilyl)-2'-O-methylcytidine 
• 108782-90-7 1-(3',5'-O-1,1,3,3-tetraisopropyl-1,3-disilyl)-β-D-ribofuranosyl-4-(2-nitrophenyl)-2-pyrimidinone 
• 110567-19-6 1-(3',5'-O-1,1,3,3-tetraisopropyl-1,3-disilyl)-β-D-ribofuranosyl-2'-O-methyl-4-(2-nitrophenyl)-2-pyrimidinone 
• 415903-48-9 3',5'-O-(1,1,3,3-tetraisopropyl-1,3-disiloxanediyl)-2'-O-(trimethylsilyl)uridine 
• 58-96-8 uridine 
• 69304-38-7 3',5'-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine 
• 1613530-40-7 C₂₃H₄₅N₃O₅Si₂ 
• 1428902-86-6 C₂₄H₄₃N₅O₅Si₂ 
• 367511-37-3 C₂₂H₄₂N₂O₆Si₂ 
• 2140-76-3 2'-O-methyluridine 
• 1085342-83-1 3',5'-di-O-acetyl-N⁴,2'-O-dimethylcytidine 

Relevant academic research and scientific papers

Synthesis and solution conformation studies of the modified nucleoside N4,2′-O-dimethylcytidine (m4Cm) and its analogues

The dimethylated ribosomal nucleoside m4Cm and its monomethylated analogues Cm and m4C were synthesized. The conformations (syn vs anti) of the three modified nucleosides and cytidine were determined by CD and 1D NOE difference spectroscopy. The ribose sugar puckers were determined by the use of proton coupling constants. The position of modification (e.g., O vs N methylation) was found to have an effect on the sugar pucker of cytidine.

ALTERNATIVE NUCLEIC ACID MOLECULES AND USES THEREOF

The present disclosure provides alternative nucleosides, nucleotides, and nucleic acids, and methods of using them.

ALTERNATIVE NUCLEIC ACID MOLECULES AND USES THEREOF

The present disclosure provides alternative nucleosides, nucleotides, and nucleic acids, and methods of using them.

Alternative nucleic acid molecules and uses thereof

The present disclosure provides alternative nucleosides, nucleotides, and nucleic acids, and methods of using them.

MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF

The present disclosure provides modified nucleosides, nucleotides, and nucleic acids, and methods of using them.

Synthesis of O2'-methyluridine, O2'-methylcytidine, N4,O2'-dimethylcytidine and N4,N4,O2'-trimethylcytidine from a common intermediate.

A facile synthesis of the title compounds from a readily accessible precursor, 3',5'-O-bis-protected O4-(2-nitrophenyl)uridine, is described.

Methylation study of ribonucleosides, deoxyribonucleosides, and 2′-O-methylribonucleosides with trimethylsulphonium hydroxide and trimethylsulphonium iodide. Influence of the 2′-hydroxy-groups on the reactivity of the base moieties of ribonucleosides

Methylations of the naturally occuring ribonucleoside (1), deoxyribonucleoside (2), and 2′-O-methylribonucleoside (3) were carried out using trimethylsulphonium hydroxide (Me3SOH) and trimethylsulphonium iodide (Me3Sl). The base moiety of (2) and (3) are more reactive than the corresponding base moiety of (1). The sites and extent of methylation of (2) are considerably different from those of (1), but are almost identical with those of (3). The reactivities of (1)-(3) are discussed in connection to an intramolecular interaction of the 2′-OH groups with the base moiety of (1). The methylating characteristics of Me 3SOH and Me3Sl are also described. The kinetics indicate an SN2 mechanism for methylation of nucleosides by Me 3S+ ions.