13048-95-8 Usage
Description
N(4), O(2')-dimethylcytidine is a modified form of the nucleoside cytidine, which is found in RNA molecules. It has two methyl groups attached to the nitrogen atom at position 4 and the oxygen atom at position 2' of the ribose sugar. This modification is involved in the regulation of gene expression and RNA processing, playing a crucial role in the modification of RNA structure and function.
Uses
Used in Biomedical Research:
N(4), O(2')-dimethylcytidine is used as a potential biomarker for certain diseases, making it an area of interest in biomedical research. Its presence in various organisms, including bacteria, plants, and animals, highlights its significance in understanding the molecular mechanisms underlying various biological processes and disease states.
Used in RNA Structure and Function Studies:
N(4), O(2')-dimethylcytidine is used as a key component in the study of RNA structure and function. Its role in the regulation of gene expression and RNA processing makes it an important molecule for researchers to investigate the intricate ways in which RNA molecules are regulated and how they contribute to cellular function and disease.
Used in Drug Development:
Given its involvement in gene expression and RNA processing, N(4), O(2')-dimethylcytidine may also be used as a target for drug development. Modulating the levels or activity of this modified nucleoside could potentially lead to the development of new therapeutics for diseases where RNA dysregulation plays a role.
Check Digit Verification of cas no
The CAS Registry Mumber 13048-95-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,3,0,4 and 8 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 13048-95:
(7*1)+(6*3)+(5*0)+(4*4)+(3*8)+(2*9)+(1*5)=88
88 % 10 = 8
So 13048-95-8 is a valid CAS Registry Number.
13048-95-8Relevant articles and documents
Synthesis and solution conformation studies of the modified nucleoside N4,2′-O-dimethylcytidine (m4Cm) and its analogues
Mahto, Santosh K.,Chow, Christine S.
, p. 8795 - 8800 (2008)
The dimethylated ribosomal nucleoside m4Cm and its monomethylated analogues Cm and m4C were synthesized. The conformations (syn vs anti) of the three modified nucleosides and cytidine were determined by CD and 1D NOE difference spectroscopy. The ribose sugar puckers were determined by the use of proton coupling constants. The position of modification (e.g., O vs N methylation) was found to have an effect on the sugar pucker of cytidine.
ALTERNATIVE NUCLEIC ACID MOLECULES AND USES THEREOF
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Page/Page column 631; 632, (2016/06/28)
The present disclosure provides alternative nucleosides, nucleotides, and nucleic acids, and methods of using them.
MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF
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Page/Page column 291, (2014/07/07)
The present disclosure provides modified nucleosides, nucleotides, and nucleic acids, and methods of using them.