36755-85-8Relevant academic research and scientific papers
Lewis acid catalyst free synthesis of substituted imidazoles in 2,2,2-trifluoroethanol
Khaksar, Samad,Alipour, Mandana
, p. 395 - 398 (2013)
A simple, inexpensive, environmentally friendly, and efficient route for the synthesis of highly substituted imidazoles by the condensation of 1,2-dicarbonyl compounds, aldehydes, and ammonium acetate using 2,2,2-trifluoroethanol as a solvent is described. The solvent can be readily separated from reaction products and recovered in excellent purity for direct reuse.
Room temperature ionic liquid promoted improved and rapid synthesis of 2,4,5-triaryl imidazoles from aryl aldehydes and 1,2-diketones or α-hydroxyketone
Siddiqui, Shapi A.,Narkhede, Umesh C.,Palimkar, Sanjay S.,Daniel, Thomas,Lahoti, Rajgopal J.,Srinivasan, Kumar V.
, p. 3539 - 3546 (2007/10/03)
An improved and rapid one-pot synthesis of 2,4,5-triaryl imidazoles in a room temperature ionic liquid is described, which does not need any added catalyst. Different ionic liquids based on 1-n-butyl and 1,3-di-n-butyl imidazolium salts were screened and their efficacy in terms of acidity and polarity have been correlated with yields and reaction period. The one-pot methodology resulting in excellent isolated yields in short reaction times is characterized by simple work up procedures and efficient recovery and recycling of the ionic liquid, which acts as a promoter.
