36757-82-1

Upstream product

• 1520-27-0 1-(4-hydroxyphenyl)thiourea 
• 74-88-4 methyl iodide 
• 123-30-8 4-amino-phenol 
• 5461-34-7 N¹-Benzoyl-N²-<4-hydroxyphenyl>thiourea 

Downstream Products

• 119321-59-4 Methyl 1-<4-Hydroxyphenyl>-2-methylmercapto-6-oxopyrimidine-4-carboxylate 
• 119321-60-7 1-<4-(1-(2-Methylmercapto-6-oxo-pyrimidinyl)phenoxy)>-3-1-(N⁴-phenylpiperazinyl)>propane 
• 119321-61-8 1-<4-(1-(2-Methylmercapto-4-methoxycarbonyl-6-oxo-pyrimidinyl)phenoxy)>-3-1-(N⁴-phenylpiperazinyl)>propane 
• 877874-86-7 4-[5-(4-trifluoromethoxy-phenyl)-4H-[1,2,4]triazol-3-ylamino]-phenol 
• 65069-90-1 N-(4-Hydroxy-phenyl)-pyrrolidine-1-carboxamidine; hydriodide 
• 877875-09-7 4-[5-(4-chloro-3-trifluoromethyl-phenyl)-4H-[1,2,4]triazol-3-ylamino]-phenol 
• 119321-58-3 1-<4-Hydroxyphenyl>-2-methylmercapto-6-oxopyrimidine 
• 119151-50-7 C₇H₁₀N₄O*HI 

Relevant academic research and scientific papers

Heterocyclic compounds useful for kinase inhibition

Provided herein are compounds useful for kinase inhibition.

HETEROCYCLIC COMPOUNDS AND METHODS OF USE

Heterocyclic compounds derived from benzotriazine, triazines, triazoles and oxadiazoles are disclosed. The methods of synthesis and of use of such heterocyclic compounds are also provided.

1,3-Disubstituted benzazepines as neuropeptide Y Y1 receptor antagonists

A novel class of potent and selective non-peptide neuropeptide Y (NPY) Y1 receptor antagonists, having benzazepine nuclei, have been designed, synthesized, and evaluated for activity. Through a blind screening we found the compound 1-N-(3-(N' -(tert-butoxycarbonyl)amino)benzyl)-7-methoxy-3-(3)-methylureido)-2,3,4,5-tetrahydro-1H-1-benzazepin-2-one (9: IC50 =1.6 μM). Chemical modifications of 9 gave a potent NPY Y1 antagonist 3-(N-(4-hydroxyphenyl)-N0 -methylguanidino)-1-N-(3-(N'-(tert- butoxycarbonyl)amino)benzyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-2-one (14c: IC50 =43 nM), which had no affnity for NPY Y2 and Y5 receptors. (C) 1999 Elsevier Science Ltd. All rights reserved.

A Versatile Synthesis of Novel N,N,N''-Trisubstituted Guanidines

N,N,N''-Trisubstituted guanidines (most of them N''-aryl-N-azacycloalkanecarboximidamides) are prepared in generally good yields by S-methylation of monosubstituted thioureas with methyl iodide in methanol or acetone and reaction of the resultant methyl c

Synthesis and Structure-Activity Relationship in 1-Aryloxy-3-1-(N4-arylpiperazinyl)>propanes

1--3-1-(N4-arylpiperazinyl)>propanes (6, 7) have been synthesized by the condensation of 1-acetyl-1,2,3,4-tetrahydroquinoline with 1-chloro-3-1-(N4-arylpiperazinyl)>propane,

Zur Kinetik der Oxydation 3-substituierter 1-Aminoguanidine durch Cerium(IV) in perchlorsaurer Loesung. 1. Teil

By known manners synthesized 1-amino-3-aryl-guanidines are oxidatively cyclized to corresponding 3,6-diarylamino-1,2,4,5-tetrazines in perchloric acid solution.The kinetics of this passing with second order model reaction was studied on a selected series of 17 1-amino-3-aryl-guanidine hydronitrates at 4 temperatures in 4 differently concentrated perchloric acid solutions of constant ionic strength by photometric concentration determination of oxidant cerium(IV).From experimental data rate constants, activation parameters and catalytic constants are evaluated by conventional methods, tabulated and discussed with regard to their substituent dependence.