7147-90-2

Usage

Uses

5-Chloroisoindoline-1,3-dione is a useful research chemical.

InChI:InChI=1/C8H4ClNO2/c9-4-1-2-5-6(3-4)8(12)10-7(5)11/h1-3H,(H,10,11,12)

Upstream product

• 3676-85-5 4-aminophthalimide 
• 118-45-6 4-chlorophthalic anhydride 
• 57-13-6 urea 
• 50-84-0 2,4 dichlorobenzoic acid 
• 544-92-3 copper(I) cyanide 
• 89-20-3 4-chlorophthalic acid 
• 96385-49-8 4-chlorophthalamide 
• 56047-23-5 monosodique de l'acide chloro-4 phtalique 
• 136918-14-4 phthalimide 
• 89-40-7 4-nitrophthalimide 
• 42348-86-7 5-chloro-1-indanone 
• 64-18-6 formic acid 
• 942319-20-2 4-chloro-2-iodobenzamide 
• 13421-13-1 4-chloro-2-iodobenzoic acid 

Downstream Products

• 623-03-0 4-Cyanochlorobenzene 
• 96385-49-8 4-chlorophthalamide 
• 6015-57-2 5-chloro-6-nitroisoindole-1,3-dione 
• 89-77-0 2-Amino-4-chlorobenzoic acid 
• 123594-04-7 4-chloroisoindoline 
• 1228312-23-9 C₁₅H₈Cl₂N₂O₂ 
• 1228312-35-3 2-(cyclohexylcarbamoyl)-N'-(2-chlorobenzylidene)-5-chlorobenzohydrazide 
• 1228312-24-0 C₁₅H₈ClFN₂O₂ 
• 1228312-36-4 2-(butylcarbamoyl)-N'-(2-fluorobenzylidene)-5-chlorobenzohydrazide 
• 1228312-37-5 2-(cyclohexylcarbamoyl)-N'-(2-fluorobenzylidene)-5-chlorobenzohydrazide 
• 1228312-38-6 2-(isopropylcarbamoyl)-N'-(4-fluorobenzylidene)-5-chlorobenzohydrazide 
• 1228312-25-1 C₁₅H₈ClFN₂O₂ 
• 1228312-39-7 2-(butylcarbamoyl)-N'-(4-fluorobenzylidene)-5-chlorobenzohydrazide 
• 1228312-40-0 2-(butylcarbamoyl)-N'-(4-(trifluoromethyl)benzylidene)-5-chlorobenzohydrazide 

Relevant academic research and scientific papers

N -Chlorinative Ring Contraction of 1,4-Dimethoxyphthalazines via a Bicyclization/Ring-Opening Mechanism

An unprecedented N -chlorinative ring contraction of 1,2-diazines was discovered and investigated with an electrophilic chlorinating reagent, trichloroisocyanuric acid (TCICA). Through optimization and mechanistic analysis, the assisting role of n -Bu 4NCl as an exogenous nucleophile was identified, and the optimized reaction conditions were applied to a range of 1,4-dimethoxyphthalazine derivatives. Also, an improvement of overall efficiency was demonstrated by the use of a labile O -silyl group. A bicyclization/ring-opening mechanism, inspired by the Favorskii rearrangement, was proposed and supported by the DFT calculations. Furthermore, the efforts on scope expansion as well as the evaluation of other electrophilic promoters revealed that the newly developed ring contraction reactivity is a unique characteristic of 1,4-dimethoxyphthalazine scaffold and TCICA.

Synthesis of N-unsubstituted cyclic imides from anhydride with urea in deep eutectic solvent (DES) choline chloride/urea

N-Unsubstituted cyclic imides were readily synthesized in deep eutectic solvent (DES) choline chloride (ChCl)/urea from anhydrides with urea. Urea serves as both a DES component and a nitrogen source, which endows the protocol with advantages of smooth reaction, easy separation of products, simple recovery and recycling of ChCl/urea.

Compound for inhibiting IDO and application of compound

The invention discloses a compound for inhibiting IDO and application of the compound, in particular to application of a compound shown in formula I, or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, or a solvate thereof, or a prod

PPh3/I2/HCOOH: An efficient CO source for the synthesis of phthalimides

A straightforward and general method has been developed for the synthesis of phthalimide derivatives from 2-iodobenzamides and PPh3/I2/HCOOH in the presence of a catalytic amount of Pd(OAc)2. The reaction results demonstrate that PPh3/I2/HCOOH is a facile, efficient and safe CO source. The whole process is carried out in toluene at 80 °C and furnishes the desired products in good to excellent yields.

Novel n-channel organic semiconductor based on pyrene-phenazine fused monoimide and bisimides

Large π-conjugated pyrene-phenazine monoimide and bisimides were synthesized by imine condensation reaction. These imides form well ordered 1D nanotapes upon self-assembly in solution. Electrochemical and electric conductivity measurement reveal it can be served as an n-channel semiconductor with large charge carrier mobility up to 4.1 cm2 V?1 s?1. Both alkylated imides are highly luminescent, and can be quenched via protonization using trifluoroacetic acid, which could be served as potential colorimetric acid sensors.

Synthesis method of phthalimide and phenyl ring-substituted phthalimide derivative

The invention provides a synthesis method of phthalimide and a phenyl ring-substituted phthalimide derivative. The synthesis method comprises that aromatic ketone and ammonia gas or an ammonia gas precursor as substrates and air or oxygen as an oxygen source undergo a reaction under catalyst action and liquid phase conditions to produce phthalimide and a phenyl ring-substituted phthalimide derivative. The synthesis method is mild, realizes high oxidation efficiency and a high product yield, utilizes oxygen or air as an oxygen source, is economic and eco-friendly and has a good application prospect.

Isoindol - 1, 3 - dione compound and its preparation method and application (by machine translation)

The invention discloses a isoindole - 1, 3 - dione compound and its preparation method and application. The general formula (I) has the structure shown. The invention of the isoindole - 1, 3 - diones to LNCap cells with cell inhibitory activity, can be used for preparing anti-tumor drug. (by machine translation)

ALLOSTERIC PROTEIN KINASE MODULATORS

The invention provides specific small molecule compounds that allosterically regulate the activity or modulate protein-protein interactions of AGC protein kinases and the Aurora family of protein kinases, methods for their production, pharmaceutical compositions comprising same, and their use for preparing medicaments for the treatment and prevention of diseases related to abnormal activities of AGC protein kinases or of protein kinases of the Aurora family.

ALLOSTERIC PROTEIN KINASE MODULATORS

The invention provides specific small molecule compounds that allosterically regulate the activity or modulate protein-protein interactions of AGC protein kinases and the Aurora family of protein kinases, methods for their production, pharmaceutical compositions comprising same, and their use for preparing medicaments for the treatment and prevention of diseases related to abnormal activities of AGC protein kinases or of protein kinases of the Aurora family.

Isoindolone derivatives, preparation process and intermediates of this process, their use as medicaments, and pharmaceutical compositions comprising them

The present invention relates to the novel isoindolone derivatives of the formula I in which R1 to R6 have the meanings stated in the claims. The inventive compounds are suitable as antiarrhythmic medicaments with a cardioprotective component for infarction prophylaxis and infarction treatment and for the treatment of angina pectoris. They also inhibit in a preventive manner the pathophysiological processes associated with the development of ischemia-induced damage, in particular in the triggering of ischemia-induced cardiac arrhythmias and of heart failure.