36775-83-4Relevant academic research and scientific papers
METHANOCARBA ADENOSINE DERIVATIVES AND DENDRIMER CONJUGATES THEREOF
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Page/Page column 34-35, (2011/06/25)
Disclosed are (N)-methanocarba adenine nucleosides, e.g., of the formula (I): as A3 adenosine receptor agonists, pharmaceutical compositions comprising such nucleosides, and a method of use of these nucleosides, wherein A, a, R2, and
2-Dialkynyl derivatives of (N)-methanocarba nucleosides: 'Clickable' A3 adenosine receptor-selective agonists
Tosh, Dilip K.,Chinn, Moshe,Yoo, Lena S.,Kang, Dong Wook,Luecke, Hans,Gao, Zhan-Guo,Jacobson, Kenneth A.
experimental part, p. 508 - 517 (2010/05/02)
We modified a series of (N)-methanocarba nucleoside 5′-uronamides to contain dialkyne groups on an extended adenine C2 substituent, as synthetic intermediates leading to potent and selective A3 adenosine receptor (AR) agonists. The proximal alk
Modulation of 11β-hydroxysteroid dehydrogenase type 1 activity by 1,5-substituted 1H-tetrazoles
Webster, Scott P.,Binnie, Margaret,McConnell, Kirsty M.M.,Sooy, Karen,Ward, Peter,Greaney, Michael F.,Vinter, Andy,Pallin, T. David,Dyke, Hazel J.,Gill, Matthew I.A.,Warner, Ines,Seckl, Jonathan R.,Walker, Brian R.
scheme or table, p. 3265 - 3271 (2010/09/14)
Inhibitors of 11β-hydroxysteroid dehydrogenase (11β-HSD1) show promise as drugs to treat metabolic disease and CNS disorders such as cognitive impairment. A series of 1,5-substituted 1H-tetrazole 11β-HSD1 inhibitors has been discovered and chemically modified. Compounds are selective for 11β-HSD1 over 11β-HSD2 and possess good cellular potency in human and murine 11β-HSD1 assays. A range of in vitro stabilities are observed in human liver microsome assays.
The synthesis of N-substituted isothiazol-3(2H)-ones from N-substituted 3-benzoylpropionamides
Hamilakis, Stylianos,Kontonassios, Demetrios,Tsolomitis, Athanase
, p. 149 - 155 (2007/10/03)
N-Substituted isothiazol-3(2H)-ones can be easily prepared from N-substituted 3-benzoylpropionamides in two experimentally simple steps, in satisfactory overall yields. Reaction of the amides with excess thionyl chloride results in the formation of N-subs
BEHAVIOUR OF N-ARYLSUCCINISOIMIDIUM PERCHLORATES TOWARDS FRIEDEL-CRAFTS AND GRINGNARD REACTIONS
Ismail, Mohamed Fekry,Enayat, Ebtesam Ismail,El Bassiouny, Fakhry Abdel Aziz,Younes, Hamed Ahmed
, p. 103 - 108 (2007/10/02)
N-Arylsuccinisoimidium perchlorates (1a and b) reacted with aromatic hydrocarbons under Friedel-Crafts conditions to give β-aroyl-N-arylpriopionamides (3a-i).The reaction of phenylmagnesium bromide with 1a and 1b proceeded via ring-opening to give 3a and
