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367906-48-7

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367906-48-7 Usage

Uses

thiazolidin e thione pharmaceutical intermediate

Check Digit Verification of cas no

The CAS Registry Mumber 367906-48-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,6,7,9,0 and 6 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 367906-48:
(8*3)+(7*6)+(6*7)+(5*9)+(4*0)+(3*6)+(2*4)+(1*8)=187
187 % 10 = 7
So 367906-48-7 is a valid CAS Registry Number.

367906-48-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-pyridyl-(2-thioxothiazolidin-3-yl)methanone

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:367906-48-7 SDS

367906-48-7Downstream Products

367906-48-7Relevant articles and documents

New dsDNA binding unnatural oligopeptides with pyrimidine selectivity

Zhang, Zhenyu,Chaltin, Patrick,Van Aerschot, Arthur,Lacey, Jeff,Rozenski, Jef,Busson, Roger,Herdewijn, Piet

, p. 3401 - 3413 (2007/10/03)

Solid phase peptide library screening followed by extension of a lead recognition element for binding to a dsDNA sequence (NF binding site of IL6) using solution phase screening, delivered a new DNA binding peptide, Ac-Arg-Ual-Sar-Chi-Chi-Tal-Arg-CONH2. In the present research, the contribution of the different amino acid side chains to the binding strength of the peptide to dsDNA was investigated using an ethidium bromide displacement test. Based on these results, the lead structure was optimized by deconvolution. Eight new unnatural amino acids were evaluated at two positions of the heptapeptide replacing the Ual-Sar fragment. The strongest dsDNA binding was observed using {[(3-chlorophenyl)methyl]amino}acetic acid (Cbg) and β-cyclohexyl-l-alanine (Cha) respectively, at those two positions. A 10-fold increase in affinity compared to the Ual-Sar sequence was obtained. Further enhancement of dsDNA binding was obtained with hybrid molecules linking the newly developed peptide fragment to an acridine derivative with a flexible spacer. This resulted in ligands with affinities in the μM range for the dsDNA target (Kd of 2.1×10-6 M). DNase I footprinting with the newly developed oligopeptide motifs showed the presence of a pronounced pyrimidine specificity, while conjugation to an intercalator seems to redirect the interaction to mixed sequences. This way, new unnatural oligopeptide motifs and hybrid molecules have been developed endowed with different sequence selectivities. The results demonstrate that the unnatural peptide library approach combined with subsequent modification of selected amino acid positions, is very suited for the discovery of novel sequence-specific dsDNA binding ligands.

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