367966-67-4

Basic information

• Product Name: (2S,4S)-1-Tert-Butyl 2-Methyl 4-((Tert-Butyldimethylsilyl)Oxy)-5-Oxopyrrolidine-1,2-Dicarboxylate
• Synonyms: (2S,4S)-1-Tert-Butyl 2-Methyl 4-((Tert-Butyldimethylsilyl)Oxy)-5-Oxopyrrolidine-1,2-Dicarboxylate;(2S,4S)-1-Tert-Butyl 2-Methyl 4-((Tert-Butyldimethylsilyl)Oxy)-5-Oxopyrrolidine-1,2-Dicarboxylate(WXC02495)
• CAS NO: 367966-67-4
• Molecular Formula: C₁₇H₃₁NO₆Si
• Molecular Weight: 373.51664
• Mol File: 367966-67-4.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (2S,4S)-1-Tert-Butyl 2-Methyl 4-((Tert-Butyldimethylsilyl)Oxy)-5-Oxopyrrolidine-1,2-Dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,4S)-1-Tert-Butyl 2-Methyl 4-((Tert-Butyldimethylsilyl)Oxy)-5-Oxopyrrolidine-1,2-Dicarboxylate(367966-67-4)
• EPA Substance Registry System: (2S,4S)-1-Tert-Butyl 2-Methyl 4-((Tert-Butyldimethylsilyl)Oxy)-5-Oxopyrrolidine-1,2-Dicarboxylate(367966-67-4)

Safety Data

• Hazardous Substances Data: 367966-67-4(Hazardous Substances Data)

Usage

General Description

"(2S,4S)-1-Tert-Butyl 2-Methyl 4-((Tert-Butyldimethylsilyl)Oxy)-5-Oxopyrrolidine-1,2-Dicarboxylate" is a chemical compound with a molecular formula of C17H29NO6Si. It is a derivative of pyrrolidine-1,2-dicarboxylate, which is commonly used in the synthesis of pharmaceutical compounds. This particular compound is a diester, with a tert-butyl group and a tert-butyldimethylsilyl group attached to the pyrrolidine ring. The presence of these groups makes it useful as a precursor or intermediate in organic synthesis. Its precise applications may vary depending on the specific processes and reactions it is involved in, but it is often used in the preparation of pharmaceuticals and other organic compounds.

Upstream product

• 74844-91-0 (2S,4S)-N-tert-butoxycarbonyl-4-hydroxyproline methyl ester 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 441067-49-8 (2S,4S)-4-hydroxypyrrolidine-2-carboxylic acid hydrochloride 
• 367966-45-8 (2S,4S)-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1,2-pyrrolidinedicarboxylic acid 1-(1,1-dimethylethyl) 2-methyl ester 

Downstream Products

• 180321-18-0 methyl (2S,4S)-4-hydroxy-5-oxopyrrolidine-2-carboxylate 
• 367966-54-9 (2S,4R)-5-Acetoxy-4-(4-chloro-naphthalen-1-yloxy)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester 
• 367966-51-6 (2S,4R)-4-(4-Chloro-naphthalen-1-yloxy)-5-hydroxy-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester 
• 367966-46-9 (2S,4R)-4-(4-Chloro-naphthalen-1-yloxy)-5-oxo-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester 
• 879899-00-0 (2R,3S)-3-benzyloxy-1-benzyloxycarbonyl-2-(2-methylprop-2-en-1-yl)piperidine 
• 879899-01-1 (2R,3S)-3-benzyloxy-2-(2-oxopropyl)piperidine-1-carboxylic acid benzyl ester 
• 879898-99-4 (2R,3S)-3-Hydroxy-2-(2-methyl-allyl)-piperidine-1-carboxylic acid benzyl ester 
• 304665-12-1 (2R,3S)-3-benzyloxy-2-[2-oxo-3-(4-oxoquinazolin-3(4H)-yl)propyl]piperidine-1-carboxylic acid benzyl ester 
• 24159-07-7 febrifugine 

Relevant articles and documents

Novel Tricyclic Pyroglutamide Derivatives as Potent RORγt Inverse Agonists Identified using a Virtual Screening Approach

Employing a virtual screening approach, we identified the pyroglutamide moiety as a nonacid replacement for the cyclohexanecarboxylic acid group which, when coupled to our previously reported conformationally locked tricyclic core, provided potent and selective RORγt inverse agonists. Structure-activity relationship optimization of the pyroglutamide moiety led to the identification of compound 18 as a potent and selective RORγt inverse agonist, albeit with poor aqueous solubility. We took advantage of the tertiary carbinol group in 18 to synthesize a phosphate prodrug, which provided good solubility, excellent exposures in mouse PK studies, and significant efficacy in a mouse model of psoriasis.

SULFONYL PYRIDYL TRP INHIBITORS

The invention is concerned with the compounds of formula I: (I) and pharmaceutically acceptable salts thereof where R1 is a substituted or unsubstituted phenyl or a fused bicyclic comprising a substituted or unsubstituted phenyl. In addition, t

Total Synthesis and Stereochemical Revision of the 2-Formylpyrrole Alkaloid Hemerocallisamine i

The first total synthesis of the 2-formylpyrrole alkaloid hemerocallisamine I is reported. The convergent synthesis features a key Maillard-Type condensation of a complex amine derived from cis-4-hydroxy-l-proline with a dihydropyranone, to directly furnish the 2-formylpyrrole ring system. The absolute configuration of hemerocallisamine I has been revised on the basis of optical rotation data obtained for the synthesized compound.