367967-67-7Relevant academic research and scientific papers
AMINO ACID DERIVATIVES
-
Page/Page column 17-18, (2009/03/07)
Compounds of formula (I) or formula (11) have dopaminergic activity: wherein: R1 is a carboxyl, carboxyl ester, or carboxamide group; R2 is a group - C(=O)-NR3R4, or -S(=O)2-NR3R4; R3 and R4 are independently selected from hydrogen,optionally substituted C1-C6 alkyl, (C1-C5 fluoroalky1)-CH2-, -Q, and -CH2Q, wherein Q is an optionally substituted monocyclic carbocyclic or heterocyclic ring of (3) to (6) ring atoms; or R3 and R4 together with the nitrogen to which they are attached form an optionally substituted monocyclic cycloalkyl or non-aromatic heterocyclic ring of (3) to (8) ring atoms; R5 is hydrogen, or a natural or non-natural alpha amino acid residue linked via a peptide bond; R6 is hydrogen or a group R7C(=O)-; and R7 is C1- C6 alkyl, C1-C6 fluoroalkyl or cyclopropyl
A convenient preparation of selectively protected L-Dopa derivatives from 3-iodo-L-tyrosine
Morera,Ortar
, p. 2115 - 2122 (2007/10/03)
Palladium-catalyzed hydroformylation of 3-iodo-L-tyrosine derivatives la,b followed by protection of the free phenol as its benzyl ether and Baeyer-Villiger oxidation of the 3-formyl group provided the desired L-Dopa derivatives 4b,c in 71 and 68% overall
