36798-25-1

Usage

Uses

Used in Pharmaceutical Industry:
C-(2-METHYL-1H-INDOL-5-YL)-METHYLAMINE is used as a synthetic intermediate for the preparation of substituted aminopyridines and aminopyrazines. These compounds are of significant interest due to their potential as protein kinase inhibitors, which play a crucial role in the regulation of various cellular processes and are often dysregulated in diseases such as cancer. By targeting these protein kinases, substituted aminopyridines and aminopyrazines may offer therapeutic benefits in the treatment of various diseases, including cancer.

InChI:InChI=1/C10H12N2/c1-7-4-9-5-8(6-11)2-3-10(9)12-7/h2-5,12H,6,11H2,1H3

Upstream product

• 58867-56-4 2-methyl-5-(phtalimidomethyl)indole 
• 95-20-5 2-methyl-1H-indole 
• 144340-21-6 1-benzenesulfonyl-1H-indole-5-carbonitrile 
• 1075-34-9 5-bromo-2-methyl-1H-indole 
• 36798-24-0 2-methyl-1H-indole-5-carbonitrile 
• 15861-24-2 1H-indole-5-carbonitrile 
• 1240112-40-6 1-benzenesulfonyl-2-methyl-1H-indole-5-carbonitrile 

Relevant academic research and scientific papers

SYNTHESIS OF BENZO(AMINOMETHYL)INDOLES

The benzene ring in indoles has been aminomethylated in high yield by reaction with methylolphtalimide followed by hydrazinolysis of the phtalimidomethyl derivatives.In the hydrazinolysis of one of the phtalimidomethyl compounds, an intermediate product (the amino-methylindole phtalazine) was isolated and characterized.

NEW POSITIVE ALLOSTERIC MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTOR

The present invention relates to indole derivatives useful in therapy, to compositions comprising said compounds, and to methods of treating diseases comprising administration of said com- pounds. The compounds referred to are positive allosteric modulators (PAMs) of the nicotinic acetylcholine α7 receptor.

Positive allosteric modulators of nicotinic acetylcholine receptor

The present invention relates to compounds useful in therapy, to compositions comprising said compounds, and to methods of treating diseases comprising administration of said compounds. The compounds referred to are positive allosteric modulators (PAMs) of the nicotinic acetylcholine α7 receptor.