36811-10-6Relevant academic research and scientific papers
Identification of the Clinical Candidate (R)-(1-(4-Fluorophenyl)-6-((1-methyl-1H-pyrazol-4-yl)sulfonyl)-4,4a,5,6,7,8-hexahydro-1H-pyrazolo[3,4-g]isoquinolin-4a-yl)(4-(trifluoromethyl)pyridin-2-yl)methanone (CORT125134): A Selective Glucocorticoid Receptor
Hunt, Hazel J.,Belanoff, Joseph K.,Walters, Iain,Gourdet, Benoit,Thomas, Jennifer,Barton, Naomi,Unitt, John,Phillips, Timothy,Swift, Denise,Eaton, Emily
, p. 3405 - 3421 (2017)
The nonselective glucocorticoid receptor (GR) antagonist mifepristone has been approved in the U.S. for the treatment of selected patients with Cushing’s syndrome. While this drug is highly effective, lack of selectivity for GR leads to unwanted side effe
METHODS OF PREPARING REGIOSELECTIVE N-ALKYL TRIAZOLES
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Paragraph 0069; 0074-0075, (2019/11/11)
Methods of preparing N-2 alkylated triazoles substantially free from N-1 and N-3 alkylated triazoles are disclosed. The methods include one-step alkylation methods and two-step alkylation methods for the preparation of N-alkylated triazoles.
HETEROARYL-KETONE FUSED AZADECALIN GLUCOCORTICOID RECEPTOR MODULATORS
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, (2014/01/07)
The present invention provides heteroaryl ketone fused azadecalin compounds and methods of using the compounds as glucocorticoid receptor modulators.
NEW METHODS AND REAGENTS IN ORGANIC SYNTHESIS. 54. LITHIUM TRIMETHYLSILYLDIAZOMETHANE: A NEW SYNTHON FOR THE PREPARATION OF 1-SUBSTITUTED 5-ALKYLTHIO-1,2,3-TRIAZOLES FROM ISOTHIOCYANATES
Aoyama, Toyohiko,Kabeya, Mototsugu,Shioiri, Takayuki
, p. 2371 - 2374 (2007/10/02)
Lithium trimethylsilyldiazomethane (1) reacts smoothly with isothiocyanates in tetrahydrofuran to give 1-substituted 4-trimethylsilyl-5-alkylthio-1,2,3-triazoles (2) after quenching with alkyl halides.Desilylation of 2 is easily achieved with 10percent aqueous potassium hydroxide in methanol to afford 1-substituted 5-alkylthio-1,2,3-triazoles (3).
