36817-69-3

Usage

Uses

Used in Pharmaceutical Industry:
(R)-9-(1-methyl-2-hydroxyethyl)adeninde is used as a pharmaceutical compound for its potential role in the development of nucleic acid-based drugs and antiviral agents. Its unique structural features contribute to its potential as a therapeutic agent.
Used in Biochemistry Research:
(R)-9-(1-methyl-2-hydroxyethyl)adeninde is used as a research tool in biochemistry for studying the interactions and mechanisms of adenine nucleosides, which can lead to a better understanding of their biological activities and potential applications in medicine.

Upstream product

• 67-56-1 methanol 
• 36817-80-8 (R)-9-(1-methyl-2-hydroxyethyl)-6-chloropurine 

Relevant academic research and scientific papers

Synthesis of acyclic nucleoside and nucleotide analogues from amino acids: A convenient approach to a PMEA-PMPA hybrid

Nonracemic amino alcohols derived from common amino acids have been used to assemble acyclic nucleoside and nucleotide analogues with control of absolute stereochemistry. Both (R)- and (S)-2-amino-1-propanol, readily available from D- or L-alanine, were used to prepare the nucleoside analogues (R)- and (S)-9-[1- methyl-2-hydroxyethyl]adenine, and then the nucleotide analogues (R)- and (S)-9-[1-methyl-2-phosphonomethoxyethyl]adenine. In a similar fashion, the CBz derivative of L-threonine was used to prepare first (1R,2R)-9-[1-hydroxymethyl-2-hydroxypropyl]adenine, and then the bis phosphonomethoxy derivative. The bis phosphonate derived from threonine represents a unique structural hybrid of PMEA and PMPA, both of which have well established antiviral activity. (C) 2000 Elsevier Science Ltd.