36824-00-7Relevant academic research and scientific papers
Rapid microwave-assisted synthesis of phenyl ethers under mildly basic and nonaqueous conditions
Sarju, Julien,Danks, Timothy N.,Wagner, Gabriele
, p. 7675 - 7677 (2004)
Microwave-assisted alkylation of phenols can be achieved within short reaction times under mild conditions using K2CO3 as a base, in methanol as a solvent. The method is suitable for base sensitive compounds or partially water-solubl
Styryl xanthine derivatives and uses thereof (by machine translation)
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Paragraph 0174; 0180; 0181; 0182; 0198; 0200; 0201; 0202, (2019/08/02)
The invention discloses styryl xanthine derivatives and application, and particularly, relates to a novel styryl xanthine derivative and a pharmaceutical composition containing the same, and can be used as selective adenosine A. 2A Are antagoni
HETEROARYL INHIBITORS OF PAD4
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Paragraph 00328-00329, (2018/03/28)
The present invention provides compounds useful as inhibitors of PAD4, compositions thereof, and methods of treating PAD4-related disorders.
Arginase inhibitor, preparation method thereof and application of arginase inhibitor
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Paragraph 0119-0122, (2018/12/02)
The invention belongs to the technical field of medicines, in particular to an arginase inhibitor and a preparation method thereof and an application of the arginase inhibitor. A compound serves as asmall-molecule treatment agent of a strong inhibitor of
Homoserine lactone derivatives, preparation method thereof and pharmaceutical composition for prevention or treatment of the periodontal diseases containing the same as an active ingredient
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Paragraph 0242-0245, (2017/04/14)
The present invention relates to homoserine lactone derivatives, optical isomers of the same, or pharmaceutically acceptable salts of the same. The homoserine lactone derivatives in the present invention have excellent properties as a quorum sensing antagonist which hinders communications among bacteria. According to the present invention, the homoserine lactone derivatives can hinder gene expressions of bacteria while effectively blocking formation of biofilm which is known to raise resistance against antibiotics, and suppress propagation of bacteria, thereby being useful as a pharmaceutical composition for preventing or treating periodontal diseases.
NOVEL SOLUBLE GUANYLATE CYCLASE ACTIVATORS AND THEIR USE
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Page/Page column 36; 37, (2015/03/28)
The invention relates to activators of soluble guanylate cyclase of formula (I) and their use in pharmaceutical compositions, primarily topically administered ophthalmic compositions. The pharmaceutical compositions are useful for reducing intraocular pre
PIPERIDINE-DIONE DERIVATIVES
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Page/Page column 131, (2015/11/10)
The invention provides novel compounds having the general formula (I) and tautomers and pharmaceutically acceptable salts thereof, wherein A1, A2, A3, A4, R1, R4, R5, R6, R7 and R8 are as defined herein, compositions including the compounds and methods of using the compounds.
GLUCOSYLCERAMIDE SYNTHASE INHIBITORS
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Page/Page column 225, (2014/04/03)
The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment of metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, cystic disease and for the treatment of cancer.
USE OF ADENOSINE A1 RECEPTOR AGONISTS FOR THE PROTECTION OF RENAL CELLS AGAINST TOXIC EFFECTS CAUSED BY AMINOGLYCOSIDES DURING TREATMENT OF INFECTIOUS DISEASES
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Page/Page column 27, (2008/06/13)
The present invention refers to the use of adenosine Al receptor agonists for the protection of renal cells against toxic effects caused by aminoglycosides during treatment of infectious diseases in human.
Imidazole derivatives
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, (2008/06/13)
The present invention relates to the imidazole derivative of the following formula (I) wherein R1 is hydrogen, optionally substituted alkyl and the like, R2 is hydrogen, optionally substituted alkyl and the like, R3is optionally substituted heteroaryl, R4 is optionally substituted cycloalkyl, optionally substituted phenyl and the like, provided that when R1 is hydrogen, and R2 and R4 are the same or different and each is phenyl or phenyl substituted by halogen atom, lower alkyl or lower alkoxy, R3 is benzothiazolyl or thiazolyl substituted by phenyl, the imidazole derivative of the following formula (XII) wherein R6 is optionally substituted phenyl or optionally substituted heteroaryl and R7 is substituted phenyl, and pharmaceutically acceptable salts thereof. The compounds of the formulas (I) and (XII) and pharmaceutically acceptable salts thereof of the present invention inhibit IL-4 and IL-5 production by Th2 cells and are effective for the prophylaxis and treatment of allergic diseases such as atopic dermatitis, bronchial asthma, allergic rhinitis and the like.
