368421-65-2

Upstream product

• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 76513-95-6 9-(β-D-ribofuranosyl)-6-(trifluoromethyl)-purine 
• 76513-94-5 (2R,3R,4R,5R)-2-(acetoxymethyl)-5-(6-(trifluoromethyl)-9H-purin-9-yl)tetrahydrofuran-3,4-diyl diacetate 
• 74465-47-7 (2R,3R,4R,5R)-2-(acetoxymethyl)-5-(6-bromo-9H-purin-9-yl)tetrahydrofuran-3,4-diyl diacetate 

Downstream Products

• 368421-66-3 5'-O-(4,4'-dimethoxytrityl)-2'-O-(t-butyldimethylsilyl)-9-(β-D-ribofuranosyl)-6-(trifluoromethyl)-purine 

Relevant academic research and scientific papers

Synthesis and analysis of RNA containing 6-trifluoromethylpurine ribonucleoside.

We report the synthesis of a 5'-DMT-2'-TBDMS-protected phosphoramidite of 6-trifluoromethylpurine ribonucleoside ((TFM)P) and its use in the site-specific incorporation of 6-trifluoromethylpurine into RNA. Properties of (TFM)P-substituted RNA suggest it will be valuable in the study of RNA structure and the binding of RNA-modifying enzymes, particularly the RNA-editing adenosine deaminases. Reaction: see text.