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(6-AMinoMethyl-1H-indazol-3-yl)aMine, also known as 6-Aminomethylindazole, is an organic compound with a unique chemical structure featuring an indazole ring and an aminomethyl group. It is a synthetic molecule that serves as a key intermediate in the development of various pharmaceutical compounds. Its chemical properties allow it to form important bonds and interactions with other molecules, making it a valuable component in the synthesis of therapeutic agents.
Source:
(6-AMinoMethyl-1H-indazol-3-yl)aMine is typically synthesized through a series of chemical reactions involving indazole and other reagents, such as alkylating agents or amines, to introduce the aminomethyl group.
Production Methods:
The production of (6-AMinoMethyl-1H-indazol-3-yl)aMine involves a multi-step synthesis process, which may include the formation of the indazole ring, followed by the introduction of the aminomethyl group through various chemical reactions, such as reductive amination or nucleophilic substitution.

368426-75-9

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368426-75-9 Usage

Uses

Used in Pharmaceutical Industry:
(6-AMinoMethyl-1H-indazol-3-yl)aMine is used as an intermediate in the preparation of thrombin inhibitors for the pharmaceutical industry. Thrombin inhibitors are essential drugs that help in the treatment of various conditions, such as deep vein thrombosis, pulmonary embolism, and acute coronary syndrome, by preventing the clotting of blood and reducing the risk of blood clot formation.
As a key component in the synthesis of thrombin inhibitors, (6-AMinoMethyl-1H-indazol-3-yl)aMine plays a crucial role in the development of new and improved medications to combat blood clot-related disorders. Its unique chemical structure allows it to form essential bonds and interactions with other molecules, contributing to the overall effectiveness of the final drug product.

Check Digit Verification of cas no

The CAS Registry Mumber 368426-75-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,6,8,4,2 and 6 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 368426-75:
(8*3)+(7*6)+(6*8)+(5*4)+(4*2)+(3*6)+(2*7)+(1*5)=179
179 % 10 = 9
So 368426-75-9 is a valid CAS Registry Number.

368426-75-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name 6-(Aminomethyl)-1H-indazol-3-amine

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

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More Details:368426-75-9 SDS

368426-75-9Downstream Products

368426-75-9Relevant academic research and scientific papers

Improving the Selectivity of PACE4 Inhibitors through Modifications of the P1 Residue

Dianati, Vahid,Navals, Pauline,Couture, Frédéric,Desjardins, Roxane,Dame, Anthony,Kwiatkowska, Anna,Day, Robert,Dory, Yves L.

, p. 11250 - 11260 (2018)

Paired basic amino acid cleaving enzyme 4 (PACE4), a serine endoprotease of the proprotein convertases family, has been recognized as a promising target for prostate cancer. We previously reported a selective and potent peptide-based inhibitor for PACE4, named the multi-Leu peptide (Ac-LLLLRVKR-NH2 sequence), which was then modified into a more potent and stable compound named C23 with the following structure: Ac-dLeu-LLLRVK-Amba (Amba: 4-amidinobenzylamide). Despite improvements in both in vitro and in vivo profiles of C23, its selectivity for PACE4 over furin was significantly reduced. We examined other Arg-mimetics instead of Amba to regain the lost selectivity. Our results indicated that the replacement of Amba with 5-(aminomethyl)picolinimidamide increased affinity for PACE4 and restored selectivity. Our results also provide a better insight on how structural differences between S1 pockets of PACE4 and furin could be employed in the rational design of selective inhibitors.

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