368426-77-1

Basic information

• Product Name: Carbamic acid, [(3-amino-1,2-benzisoxazol-6-yl)methyl]-, 1,1-dimethylethyl ester
• CAS NO: 368426-77-1
• Molecular Formula: C13H17N3O3
• Molecular Weight: 263.296
• Mol File: 368426-77-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [(3-amino-1,2-benzisoxazol-6-yl)methyl]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [(3-amino-1,2-benzisoxazol-6-yl)methyl]-, 1,1-dimethylethyl ester(368426-77-1)
• EPA Substance Registry System: Carbamic acid, [(3-amino-1,2-benzisoxazol-6-yl)methyl]-, 1,1-dimethylethyl ester(368426-77-1)

Safety Data

• Hazardous Substances Data: 368426-77-1(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 368426-73-7 4-(aminomethyl)-2-fluorobenzonitrile 
• 368426-72-6 4-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-2-fluoro-benzonitrile 
• 222978-03-2 4-cyano-3-fluorobenzylbromide 
• 452-74-4 4-bromo-3-fluorotoluene 
• 229623-55-6 4-(tert-butoxycarbonylaminomethyl)-2-fluorobenzonitrile 
• 85070-67-3 2-fluoro-4-methylbenzonitrile 

Downstream Products

• 368426-78-2 6-aminomethyl-benzo[d]isoxazol-3-ylamine 

Relevant articles and documents

MASP-2 INHIBITORS AND METHODS OF USE

The present disclosure provides, inter alia, compounds with MASP-2 inhibitory activity, compositions of such compounds and methods of making and using such compounds.

Non-covalent thrombin inhibitors featuring P3-heterocycles with P1-bicyclic arginine surrogates

Novel, potent, and highly selective classes of thrombin inhibitors were identified, which resulted from judicious combination of P4-aromatics and P2-P3-heterocyclic dipeptide surrogates with weakly basic (calcd pKa ～non-basic - 8.6) bicyclic P1-arginine mimics. The design, synthesis, and biological activity of achiral, non-covalent, orally bioavailable inhibitors NC1-NC44 featuring P1-indazoles, benzimidazoles, indoles, benzotriazoles, and aminobenzisoxazoles is disclosed.