368435-46-5

Upstream product

• 219589-42-1 3-iodo-5-nitrobenzyl alcohol 
• 90390-46-8 (3-amino-5-nitrophenyl)methanol 
• 99-34-3 3,5-dinitrobenzoic acid 
• 1620809-34-8 ethyl 3-azido-5-iodobenzoate 
• 1620809-38-2 (3-ethoxycarbonyl-5-iodo)phenylboronic acid pinacol ester 
• 58313-23-8 3-iodobenzoic acid methyl ester 
• 71022-43-0 3,5-dinitrobenzyl alcohol 

Downstream Products

• 528893-97-2 3-azido-5-iodobenzyl alcohol 
• 528893-95-0 (3-azido-5-iodo)benzyl bromide 
• 849607-20-1 3-azido-5-(2-(trimethylsilyl)ethynyl)benzyl alcohol 

Relevant academic research and scientific papers

Synthesis of diverse 3-azido-5-(azidomethyl)benzene derivatives via formal C-H azidation and functional group-selective transformations

3-Azido-5-(azidomethyl)benzene derivatives are useful compounds for preparing diverse bistriazole compounds and photoaffinity probes for target identification of bioactive compounds. To more easily synthesize a diverse range of diazido compounds, a facile

Synthesis of polynorbornene with pendant moiety bearing azide and terminal alkyne groups

A powerful approach to the synthesis of an unprecedented polynorbornene with pendant moiety bearing azide and terminal alkyne groups is developed. Two key intermediates, namely, 3-azido-5-(2-(trimethylsilyl)ethynyl) benzyl alcohol and 4-(4-aza-tricyclo [5.2.1.02.6]dec-8-en-4-yl) benzoic acid, were optimally synthesized for convergent synthesis of the corresponding monomer.

[(125)I]-N-[(3-azido-5-iodo)benzyl]dantrolene and [(125)I]-N-[[3-iodo-5-(3-trifluoromethyl-3H-diazirin-3-yl)]benzyl]dantrolene: photoaffinity probes specific for the physiological Ca(2+) release from sarcoplasmic reticulum of skeletal muscle.

In order to capture and identify key molecules that regulate the release of Ca(2+) from the sarcoplasmic reticulum (SR) of skeletal muscle, we designed specific photoaffinity probes based on the structural modification of dantrolene. Thus, GIF-0082 and GIF-0276 possessing azido- and trifluoromethyldiazirinyl-benzyl groups, respectively, at the hydantoin moiety were found to have a highly selective inhibitory effect on physiological Ca(2+) release (PCR) without affecting Ca(2+)-induced Ca(2+) release (CICR). Successful realization of the sharp discrimination between PCR and CICR has led to the creation of [(125)I]GIF-0082 and [(125)I]GIF-0276, which were synthesized by substituting a stannyl group with (125)I in the corresponding phenylstannane precursors.