368447-50-1

Upstream product

• 53744-33-5 3-(2-naphthalenyl)-1-phenylprop-2-en-1-one 
• 109-77-3 malononitrile 
• 42299-50-3 (2E)-1-phenyl-3-(2-naphthyl)-2-propen-1-one 
• 98-86-2 acetophenone 
• 66-99-9 β-naphthaldehyde 

Downstream Products

• 474902-18-6 2-bromo-4-(2-naphthalenyl)-6-phenyl-3-pyridinecarbonitrile 

Relevant academic research and scientific papers

One-Pot Quinine-Catalyzed Synthesis of α-Chiral γ-Keto Esters: Enantioenriched Precursors of cis-α,γ-Substituted-γ-Butyrolactones

A highly enantioselective one-pot synthesis of important building blocks, α-chiral γ-keto esters, has been developed by combining a quinine-catalyzed Michael addition of malononitrile to trans-enones followed by magnesium monoperoxyphthalate (MMPP) oxidat

An active and selective heterogeneous catalytic system for Michael addition

Potassium fluoride doped natural zeolite was found to be an efficient and selective solid base catalyst for 1,4-Michael addition. The catalyst is easily prepared and the workup procedure simplified by simple filtration. All products were obtained in high

Back to natural cinchona alkaloids: Highly enantioselective Michael addition of malononitrile to enones

An efficient and convenient highly enantioselective Michael addition of malononitrile to enones has been developed by using quinine as the organocatalyst. The adducts were isolated in excellent yield and high asymmetric induction (up to 95% ee). An easy r

New 3-pyridinecarbonitrile derivatives and their antimicrobial properties

2-Alkoxy-4,6-diaryl-3-pyridinecarbonitriles 2a-f were prepared through the reaction of 1,3-diaryl-2-propen-1-ones 1a-c with malononitrile in the appropriate alcohol in the presence of sodium. The reaction was assumed to take place through Michael addition followed by cyclization due to the alkoxide nucleophilic attack at one of the nitrile groups. This assumption was substantiated by isolation of the open-chain Michael adduct 4, followed by independent cyclization to the corresponding 2-alkoxy-3-pyridinecarbonitriles 2 upon treatment with the appropriate alcohol in the presence of sodium. Bromination of 4a.b with bromine in glacial acetic acid, afforded directly the corresponding 2-bromo-3-pyridinecarbonitriles 6a.b. The latters readily underwent nucleophilic substitution with different amines. The antimicrobial properties of the prepared compounds against Gram positive, Gram-negative, acid-fast bacteria and yeast were screened. Many of the prepared compounds show remarkable antimicrobial activity.

Stereoselective reductive radical cyclization of ketonitriles catalyzed by Cp2TiCl2 in the presence of chlorosilane and zinc

Reductive radical cyclization of ketonitriles was catalyzed by Cp2TiCl2 in the presence of Me3SiCl, zinc powder and imidazole, giving the 2-amino-3-cyano-2-cyclopenten-1-ols in moderate to good yields with high trans selec

In vitro antifungal evaluation and structure-activity relationships of a new series of chalcone derivatives and synthetic analogues, with inhibitory properties against polymers of the fungal cell wall

Here we report the synthesis, in vitro antifungal evaluation and SAR study of 41 chalcones and analogues. In addition, all active structures were tested for their capacity of inhibiting Saccharomyces cerevisiae β(1,3)-glucan synthase and chitin synthase,