36855-68-2Relevant articles and documents
Discovery and initial SAR of inhibitors of interleukin-1 receptor-associated kinase-4
Powers, Jay P.,Li, Shyun,Jaen, Juan C.,Liu, Jinqian,Walker, Nigel P.C.,Wang, Zhulun,Wesche, Holger
, p. 2842 - 2845 (2007/10/03)
High-throughput screening of a small-molecule compound library resulted in the identification of a novel series of N-acyl 2-aminobenzimidazoles that are potent inhibitors of interleukin-1 receptor-associated kinase-4.
Synthesis, crystal structure determination and antiproliferative evaluation of novel benzazoyl benzamides
Starcevic, Kristina,Caleta, Irena,Cincic, Dominik,Kaitner, Branko,Kralj, Marijeta,Ester, Katja,Karminski-Zamola, Grace
, p. 2285 - 2299 (2007/10/03)
A series of benzazoyl-benzamides containing different substituents (7-17) were synthesized by condensation of 2-aminobenzazole derivatives (3a-6) with p-substituted benzoyl chlorides. All compounds were characterized by IR, 1H and 13C NMR, MS and elemental analysis. Crystal structure was determined for the compound (9). Some of the new synthesized compounds (7-17) were screened for antitumor activities. Based on presented in vitro screening results we may conclude that compounds (10, 15a, 15b and 16) showed accentuated cell growth inhibitory activity.
Tautomerie von Heterocyclen, VIII. N-Acylsubstituierte Chlorformamidine als Heterocyclen- Bausteine
Ried, Walter,Erle, Hanns-Eberhard
, p. 475 - 482 (2007/10/02)
N-(4-Nitrobenzoyl)-1-pyrrolidinecarbimidoyl chloride (1) reacts with bisnucleophilic reagents according to two possible pathways to differently structured heterocyclic compounds.In path A following the substitution of the chlorine atom ring closure from t