36855-68-2Relevant academic research and scientific papers
Discovery and initial SAR of inhibitors of interleukin-1 receptor-associated kinase-4
Powers, Jay P.,Li, Shyun,Jaen, Juan C.,Liu, Jinqian,Walker, Nigel P.C.,Wang, Zhulun,Wesche, Holger
, p. 2842 - 2845 (2007/10/03)
High-throughput screening of a small-molecule compound library resulted in the identification of a novel series of N-acyl 2-aminobenzimidazoles that are potent inhibitors of interleukin-1 receptor-associated kinase-4.
13C NMR spectra and biological activity of N-(1H-benzimidazol-2- yl)benzamides
Pilyugin,Sapozhnikov,Davydov,Chikisheva,Vorob'eva,Klimakova,Kiseleva,Kuznetsova,Davletov,Sapozhnikova,Yumadilov
, p. 1653 - 1659 (2008/02/09)
Derivatives of 1H-benzimidazol-2-amine and halo-, nitro-, methoxy-, and hydroxy-substituted benzoic acids were synthesized, and their fungicide activity against pure Fusarium culmorum and Helminthosporium sativum cultures and pathogenic microflora of wheat and barley seeds in laboratory and field tests was studied. Some compounds were found to exhibit a strong fungicide activity. Nauka/Interperiodica 2006.
Synthesis, crystal structure determination and antiproliferative evaluation of novel benzazoyl benzamides
Starcevic, Kristina,Caleta, Irena,Cincic, Dominik,Kaitner, Branko,Kralj, Marijeta,Ester, Katja,Karminski-Zamola, Grace
, p. 2285 - 2299 (2007/10/03)
A series of benzazoyl-benzamides containing different substituents (7-17) were synthesized by condensation of 2-aminobenzazole derivatives (3a-6) with p-substituted benzoyl chlorides. All compounds were characterized by IR, 1H and 13C NMR, MS and elemental analysis. Crystal structure was determined for the compound (9). Some of the new synthesized compounds (7-17) were screened for antitumor activities. Based on presented in vitro screening results we may conclude that compounds (10, 15a, 15b and 16) showed accentuated cell growth inhibitory activity.
SYNTHESIS OF 4-ARYL BENZIMIDAZOLO-s-TRIAZIN-2-ONES AND 2-AROYLAMINOBENZIMIDAZOLO-1,2,4-THIADIAZOLINES
Sridevi, G.,Rao, P. Jayaprasad,Reddy, K. Kondal
, p. 965 - 972 (2007/10/02)
Reaction of 2-aminobenzimidazole with aroylisothiocyanates gave 2-aroylaminobenzimidazoles (3) and N-aroyl-N'-(benzimidazol-2-yl)-thioureas (4).The products obtained on reaction of 4 with PCl5 in POCl3 , and with oxidising agents have been identified as 4
Tautomerie von Heterocyclen, VIII. N-Acylsubstituierte Chlorformamidine als Heterocyclen- Bausteine
Ried, Walter,Erle, Hanns-Eberhard
, p. 475 - 482 (2007/10/02)
N-(4-Nitrobenzoyl)-1-pyrrolidinecarbimidoyl chloride (1) reacts with bisnucleophilic reagents according to two possible pathways to differently structured heterocyclic compounds.In path A following the substitution of the chlorine atom ring closure from t
