36855-80-8

Usage

Uses

4-Amino-N-2-benzothiazolylbenzamide is useful in the synthesis of antiulcer agents.

InChI:InChI=1/C14H11N3OS/c15-10-7-5-9(6-8-10)13(18)17-14-16-11-3-1-2-4-12(11)19-14/h1-8H,15H2,(H,16,17,18)

Upstream product

• 35353-21-0 N-(benzo[d]thiazol-2-yl)-4-nitrobenzamide 
• 136-95-8 2-amino-benzthiazole 
• 122-04-3 4-nitro-benzoyl chloride 
• 16106-38-0 4-aminobenzoyl chloride 

Relevant academic research and scientific papers

Synthesis of Novel Corrosion Inhibitor N-(1,3-benzothiazol-2-yl)-4-aminobenzamide in 1 N hydrochloric acid medium

A novel corrosion inhibitor i.e. N-(1,3-benzothiazol-2-yl)-4-aminobenzamide was synthesized and its corrosion inhibitor on controlling the rate of mild steel material in hydrochloric acid medium (1 N) at different temperatures was investigated. Rate of corrosion and inhibition efficiency were analyzed and calculated using mass loss method and electrochemical studies. As the concentration of the inhibitor increase the inhibitor efficiency also increases gradually with decrease in the rate of corrosion. Therefore from this study the efficiency of the inhibitor was good at different temperature in 1 N HCl. The relative corrosion inhibition efficiency of synthesized organic compound has been explained on the basis of its structure dependent-electron donating properties of the inhibitor. Further the structure and compound present in the synthesized organic inhibitor compound was confirmed by FTIR and NMR studies.

Tumor-Activated Benzothiazole Inhibitors of Stearoyl-CoA Desaturase

A series of N-acyl benzothiazoles shows selective and potent cytotoxicity against cancer cell lines expressing cytochrome P450 4F11. A prodrug form is metabolized by cancer cells into an active inhibitor of stearoyl-CoA desaturase (SCD). Substantial variation on the acyl portion of the inhibitors allowed the identification of (R)-27, which balanced potency, solubility, and lipophilicity to allow proof-of-concept studies in mice. The prodrugs were activated inside the tumor, where they can arrest tumor growth. Together, these observations offer promise that a tumor-activated prodrug strategy might exploit the essentiality of SCD for tumor growth, while avoiding toxicity associated with systemic SCD inhibition.

2, 3-Butanediamide Epoxide Compound and Preparation Method and Use Thereof

Provided are a compound of formula I which can be used as a drug against small RNA virus infections, and optical isomers, pharmaceutically acceptable salts, solvates or hydrates thereof. Also provided are the preparation method of the compound, the method for using the compound for treating bacterial infections and the use of the compound in the preparation of a drug for preventing and/or treating viral diseases caused by small RNA viruses.