36875-26-0Relevant articles and documents
Lipid A analogs having immunoactivating and anti-tumor activity
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, (2008/06/13)
Compounds of formula (I): STR1 in which: R1 is hydroxy, protected hydroxy, fluorine, or --OP(O)(OH)2 ; R2 and R3 are independently optionally substituted C6 -C20 aliphatic acyl; R4 is hydroxy, protected hydroxy, or --OP(O)(OH)2, where at least one of R1 and R4 is --OP(O)(OH)2 ; and R5 is hydroxy, protected hydroxy, or fluorine; provided that, except where at least one of R1 and R5 is fluorine, then at least one of R2 and R3 is a substituted C6 -C20 aliphatic acyl having (i) at least one halogen substituent and (ii) at least one substituent selected from the group consisting of halogen, hydroxy and C6 -C20 aliphatic acyloxy or at least one of R2 and R3 is a substituted C6 -C20 aliphatic acyl which is substituted by at least one halogen-substituted C6 -C20 aliphatic carboxylic acyloxy; have Lipid A-like activity and may be used for the treatment, prophylaxis, diagnosis and support of an animal suffering a disease or disorder arising from a deficiency in the immune system or from a tumor. They may be prepared by phosphorylation of corresponding compounds lacking a phosphoryl group.