3688-65-1Relevant articles and documents
Efficient N-Demethylation of Opiate Alkaloids Using a Modified Nonclassical Polonovski Reaction
McCamley, Kristy,Ripper, Justin A.,Singer, Robert D.,Scammells, Peter J.
, p. 9847 - 9850 (2007/10/03)
A modified Polonovski reaction has been employed to N-demethylate several opiate alkaloids in moderate to high yield. This method provides an alternative to traditional N-demethylation procedures which utilize toxic reagents such as cyanogen bromide or expensive reagents such as vinyl chloroformate. The current synthesis involves N-oxide formation, isolation of the corresponding N-oxide hydrochloride, and an FeS04·7H20 mediated Polonovski reaction to afford the desired secondary amine.
On the analysis and the stability of codeine phosphate. Part 1: Detection and determination of codeine in the presence of degradation products
Gundermann,Pohloudek-Fabini
, p. 296 - 299 (2007/10/02)
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