3688-89-9Relevant articles and documents
CONDENSED HETEROCYCLIC COMPOUND
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Paragraph 0628; 0629, (2018/01/09)
The present invention relates to a condensed heterocyclic compound that has an enteropeptidase inhibitory effect and is useful in the treatment or prevention of obesity, diabetes mellitus, or the like, and a medicament containing the same. Specifically, t
Expeditious synthesis of benzopyrans via lewis acid-catalyzed C-H functionalization: Remarkable enhancement of reactivity by an ortho substituent
Mori, Keiji,Kawasaki, Taro,Sueoka, Shosaku,Akiyama, Takahiko
supporting information; experimental part, p. 1732 - 1735 (2010/09/05)
An expeditious construction of a benzopyran skeleton via Lewis acid-catalyzed C-H functionalization was achieved. In this process, a [1,5] hydride shift and 6-endo cyclization successively occurred to give benzopyrans. The presence of substituents ortho to the alkoxy group significantly enhanced the reactivity, affording the desired compounds in excellent chemical yields with short reaction times.
TEREPHTHALAMATE COMPOUNDS AND COMPOSITIONS, AND THEIR USE AS HIV INTEGRASE INHIBITORS
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Page/Page column 32, (2008/12/06)
Described herein are compounds having a terephthalamate structural feature. Also described herein, are methods of making such compounds, methods of using such compounds to modulate the activity of HIV integrase, and pharmaceutical compositions and medicaments comprising such compounds. Also described herein are methods of using such compounds, pharmaceutical compositions and medicaments to treat and/or prevent and/or inhibit and/or ameliorate the pathology and/or symptomology of AIDS or infection with HIV.
Synthesis of bis(catechol) ligands derived from Troeger's base and their dinuclear triple-stranded complexes with titanium(IV) ions
Kiehne, Ulf,Luetzen, Arne
, p. 5703 - 5711 (2008/09/17)
Bis(catechol) ligands derived from 2,8-disubstituted analogues of Troeger's base and monofunctionalized MOM-protected or unprotected catechols bearing both rigid and flexible spacers were synthesized, which gave rise to dissymmetric oxygen donor ligands w
Combined Directed ortho Metalation/Suzuki-Miyaura cross-coupling strategies. Regiospecific synthesis of chlorodihydroxybiphenyls and polychlorinated biphenyls
Nerdinger,Kendall,Cai,Marchart,Riebel,Johnson,Yin,Henaff,Eltis,Snieckus
, p. 5960 - 5967 (2008/02/09)
(Chemical Equation Presented) The Directed ortho Metalation (DoM)/Suzuki-Miyaura cross-coupling strategy is applied for the regiospecific construction of all isomeric monochloro and selected dichloro and trichloro 2,3-dihydroxybiphenyls (DHBs). The combined methodology highlights iterative DoM processes, hindered Suzuki-Miyaura couplings, and advantages in diversity in approaches from commercial starting materials leading to provision of chloro-DHBs as single isomers in high purity and on a gram scale. The syntheis of several PCBs are also reported.
Synthesis of two naturally occurring 3-methyl-2,5-dihydro-1-benzoxepin carboxylic acids
Yamaguchi, Seiji,Tsuchida, Nao,Miyazawa, Masahiro,Hirai, Yoshiro
, p. 7505 - 7511 (2007/10/03)
Two naturally occurring 3-methyl-2,5-dihydro-1-benzoxepin carboxylic acids, 6-hydroxy-3-methyl-8-(phenylethyl)-2,5-dihydro-1-benzoxepin-9-carboxylic acid (radulanin E) (1) and 9-hydroxy-3-methyl-2,5-dihydro-1-benzoxepin-7-carboxylic acid (2), were synthes
AMALOGUES MORPHINIQUES DERIVES DES TETRA- ET HEXAHYDRODIBENZOFURANES I - SYNTHESE ET EPOXYDATION STEREOSPECIQUES DES ARYLALKYLCYCLOHEXENES INTERMEDIAIRES
Labidalle, Serge,Min, Zhang Yong,Reynet, Annick,Moskowitz, Henri,Vierfond, Jean-Michel,et al.
, p. 1159 - 1170 (2007/10/02)
Par transposition de Claisen-Eachenmoser, on a fixe sur une serie d'aryl-1 cyclohexena-1 ols-2 une chaine dimethylacetamidee.Une epoxydation stereospecifique des composes obtenus conduit a des composes bicyclique intermediares dans la synthese d'analogues morphiniques.