368871-33-4

Upstream product

• 109183-71-3 N-(tert-butoxycarbonyl)-L-cyclohexylglycine 
• 74844-93-2 N-BOC-3,4-didehydro-(S)-proline methyl ester 
• 367258-44-4 ({3-[(tert-butoxycarbonyl)amino]-2-hydroxyhexanoyl}amino)acetic acid 
• 166196-06-1 3-tert-butoxycarbonylamino-2-hydroxyhexanoic acid 
• 873676-51-8 C₂₅H₃₂N₂O₇ 
• 873676-48-3 (2S,3aR,4S,6aS)-2-(3-Benzyloxy-propyl)-5-{(S)-2-cyclohexyl-2-[2-(3-hydroxy-phenyl)-acetylamino]-acetyl}-tetrahydro-[1,3]dioxolo[4,5-c]pyrrole-4-carboxylic acid methyl ester 
• 873676-49-4 (2S,3aR,4S,6aS)-5-{(S)-2-Cyclohexyl-2-[2-(3-hydroxy-phenyl)-acetylamino]-acetyl}-2-(3-hydroxy-propyl)-tetrahydro-[1,3]dioxolo[4,5-c]pyrrole-4-carboxylic acid methyl ester 
• 873676-47-2 (2S,3aR,4S,6aS)-2-(3-Benzyloxy-propyl)-5-((S)-2-tert-butoxycarbonylamino-2-cyclohexyl-acetyl)-tetrahydro-[1,3]dioxolo[4,5-c]pyrrole-4-carboxylic acid methyl ester 
• 873676-50-7 C₂₆H₃₄N₂O₇ 
• 367258-46-6 {1-[({[(dimethylcarbamoyl-phenyl-methyl)-carbamoyl]-methyl}-carbamoyl)-hydroxy-methyl]-butyl}-carbamic acid tert-butyl ester 
• 873676-44-9 (2S,3aR,4S,6aS)-2-(3-Benzyloxy-propyl)-tetrahydro-[1,3]dioxolo[4,5-c]pyrrole-4,5-dicarboxylic acid 5-tert-butyl ester 4-methyl ester 
• 367258-43-3 (3-tert-butoxycarbonylamino-2-hydroxyhexanoylamino)acetic acid benzyl ester 

Relevant academic research and scientific papers

Proline-based macrocyclic inhibitors of the hepatitis C virus: Stereoselective synthesis and biological activity

Life-saving donut: Macrocyclization through a Mitsunobu reaction was used to synthesize a 17-membered macrocycle. The bicyclic acetal core was prepared completely diastereoselectively. The macrocyclic peptidomimetic surrogate of the P2-P3 dipeptide moiety was designed to function as a hepatitis C virus (HCV) NS3 serine protease inhibitor, and the pentapeptide α-ketoamides derived from the macrocycle were shown to be potent HCV inhibitors. (Figure Presented).