74844-93-2Relevant articles and documents
Synthetic Marine Sponge Collagen by Late-Stage Dihydroxylation
Priem, Christoph,Geyer, Armin
, p. 162 - 165 (2018/01/17)
Based on the observation that an increased substrate size is paralleled by an enhanced diastereoselectivity, a late-stage dihydroxylation protocol toward the 21mer CMP (collagen model peptide) Ac-(Pro-Hyp-Gly)3-Pro-Dyp-Gly-(Pro-Hyp-Gly)3-NH2 is presented. C3 and C4 hydroxylation have a converse effect on the triple-helical stability of collagen. Their combined influence on the melting temperature was studied by NMR spectroscopy.
METHOD FOR PRODUCING FLUORINATED PROLINE DERIVATIVE
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Page/Page column 36-38, (2008/06/13)
Disclosed is a method for efficiently producing a high-purity fluorinated proline derivative with high yield. Specifically disclosed is a method for producing a compound represented by the general formula (2) below wherein a compound represented by the formula (1) below is reacted with a fluorination agent, and then chlorine, bromine, iodine, hypochlorous acid, hypochlorite, hypobromous acid, hypobromite or N-halogenosuccinimide is caused to act on the reaction product obtained by the preceding reaction and containing the compound represented by the general formula (2) below and a by-product for chemically changing the by-product. (1) (In the formula (1), R1 represents an unsubstituted or substituted alkyl group having 1-6 carbon atoms or the like; R2 represents an unsubstituted or substituted alkyl group having 1-6 carbon atoms or the like; and R3 represents a hydroxyl group or the like.) (2) (In the formula (2), R1 and R2 are as defined above.)
Direktes Verfahren zur Synthese von N-Boc-L-3,4-Didehydroprolin
Dormoy, Jean-Robert,Castro, Bertrand,Chappuis, Georges,Fritschi, Ulrich-Stefan,Grogg, Peter
, p. 761 (2007/10/02)
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