368878-09-5Relevant articles and documents
Synthesis of 21-nor-22-oxa-1Iα,25-dihydroxyvitamin D3 derivatives in quest of a drug with low calcemic activity
Shimizu, Hitoshi,Shimizu, Kazuki,Uchiyama, Yasushi,Sugita, Atsuko,Mikami, Tetsuhiro,Yamauchi, Tsuyoshi,Kato, Masahiro,Morikawa, Kazumi
, p. 7837 - 7841 (2007/10/03)
Two 21-nor-22-oxa-1α,25-dihydroxyvitamin D3 derivatives have been synthesized in quest of a drug with lower calcemic activity than Maxacalcitol, 22-oxa-1α,25-dihydroxyvitamin D3, being used as antihyperparathyroidism and antipsoriatic drug. Of two 21-nor products obtained, the product carrying one carbon elongated side chain with diethylcarbinol moiety has been found to exhibit comparable differentiation-inducing activity to Maxacalcitol with much lower exhibition of calcemic activity.