36889-13-1 Usage
Description
L-NIO is a non-selective inhibitor of all NOS isoforms. The Ki values for nNOS (rat), eNOS (bovine), and iNOS (mouse) are 1.7, 3.9, and 3.9 μM, respectively. L-NIO inhibits endothelial-dependent relaxation induced by acetylcholine in rat aortic rings and hypotensive responses to acetylcholine and bradykinin.
Chemical Properties
White Crystalline Solid
Uses
A potent and reversible inhibitor of NO synthase of adrenal glands, brain, and vascular endothelial cells
Biological Activity
Potent inhibitor of endothelial NO synthase (IC 50 = 500 nM). Also inhibits iNOS and nNOS. Active in vivo .
Check Digit Verification of cas no
The CAS Registry Mumber 36889-13-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,6,8,8 and 9 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 36889-13:
(7*3)+(6*6)+(5*8)+(4*8)+(3*9)+(2*1)+(1*3)=161
161 % 10 = 1
So 36889-13-1 is a valid CAS Registry Number.
InChI:InChI=1/C7H15N3O2/c1-5(8)10-4-2-3-6(9)7(11)12/h6H,2-4,9H2,1H3,(H2,8,10)(H,11,12)/p+1/t6-/m0/s1