952664-95-8 Usage
Uses
Used in Pharmaceutical Development:
2-(tert-Butyl)-7-fluoro-1H-indol-5-amine is used as a chemical scaffold for the development of new pharmaceutical agents, leveraging its potential anti-inflammatory, anti-cancer, and anti-microbial properties. The presence of the tert-butyl and fluorine groups may confer advantageous pharmacokinetic and pharmacodynamic properties, making it a valuable candidate for further research and development.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 2-(tert-Butyl)-7-fluoro-1H-indol-5-amine serves as a starting point for the synthesis of new compounds with improved therapeutic effects. Its unique structural features allow for the exploration of various chemical modifications, potentially leading to the discovery of more effective and safer drugs.
Used in Drug Design and Optimization:
2-(tert-Butyl)-7-fluoro-1H-indol-5-amine is utilized in drug design and optimization processes to create molecules with enhanced potency, selectivity, and reduced side effects. Its indole core and substituents provide a foundation for structure-activity relationship studies, guiding the design of more efficacious and targeted therapeutic agents.
Used in Biochemical and Molecular Biology Studies:
2-(tert-Butyl)-7-fluoro-1H-indol-5-amine may also be employed in biochemical and molecular biology research to investigate the mechanisms of action of indole-based drugs. It can be used as a tool to probe the interactions between ligands and their biological targets, providing insights into the development of more selective and potent therapeutic agents.
Overall, 2-(tert-Butyl)-7-fluoro-1H-indol-5-amine is a versatile chemical entity with broad applications in the pharmaceutical and chemical sciences, warranting further exploration to harness its full potential in drug discovery and development.
Check Digit Verification of cas no
The CAS Registry Mumber 952664-95-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,5,2,6,6 and 4 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 952664-95:
(8*9)+(7*5)+(6*2)+(5*6)+(4*6)+(3*4)+(2*9)+(1*5)=208
208 % 10 = 8
So 952664-95-8 is a valid CAS Registry Number.
952664-95-8Relevant academic research and scientific papers
Compositions for Treatment of Cystic Fibrosis and Other Chronic Diseases
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, (2015/09/22)
The present invention relates to pharmaceutical compositions comprising an inhibitor of epithelial sodium channel activity in combination with at least one ABC Transporter modulator compound of Formula A, Formula B, Formula C, or Formula D. The invention also relates to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis using the pharmaceutical combination compositions.
COMPOSITIONS FOR TREATMENT OF CYSTIC FIBROSIS AND OTHER CHRONIC DISEASES
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, (2012/04/23)
The present invention relates to pharmaceutical compositions comprising an inhibitor of epithelial sodium channel activity in combination with at least one ABC Transporter modulator compound of Formula A, Formula B, Formula C, or Formula D. The invention also relates to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis using the pharmaceutical combination compositions.
Modulators of ATP-binding cassette transporters
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Page/Page column 124, (2008/06/13)
Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
