36901-99-2 Usage
General Description
1-(2-cyanoethyl)pyrrolidine-2-carboxylic acid 1-oxide, also known as CEPC, is a chemical compound that is commonly used as a reagent in organic synthesis. It is a versatile building block in the preparation of various pharmaceuticals and bioactive compounds. CEPC contains a pyrrolidine ring, a carboxylic acid group, and a nitrile group, which allows it to participate in a wide range of chemical reactions. It is also a stable and easily handled compound, making it a valuable tool in the development of new molecules and drugs. CEPC's unique structure and functional groups make it an important and valuable chemical in the field of organic chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 36901-99-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,6,9,0 and 1 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 36901-99:
(7*3)+(6*6)+(5*9)+(4*0)+(3*1)+(2*9)+(1*9)=132
132 % 10 = 2
So 36901-99-2 is a valid CAS Registry Number.
36901-99-2Relevant articles and documents
A Convenient On-Site Oxidation Strategy for the N -Hydroxylation of Melanostatin Neuropeptide Using Cope Elimination
Correia, Xavier Cruz,Costa-Almeida, Hugo F.,Pires-Lima, Beatriz L.,Sampaio-Dias, Ivo E.,Silva-Reis, Sara C.
, (2022/02/16)
A convenient synthetic protocol for the unprecedented N-hydroxylation of proline residue in Melanostatin (MIF-1) neuropeptide is reported. This methodology is grounded on the incorporation of N-(cyanoethyl)prolyl residue followed by on-site oxidation by Cope elimination with m-chloroperbenzoic acid, exploring the unrecognized dual role of the cyanoethyl group as an effective N-protecting group under peptide synthesis conditions and as a suitable leaving group during the chemoselective on-site N-oxidation. Following this protocol N-hydroxy-MIF-1 is obtained in 78% global yield from N-(cyanoethyl)-Lproline. This synthetic approach opens a new avenue for access to N-hydroxylated Melanostatin analogues with direct application in neurochemistry and Parkinson s research.
