36913-39-0

Basic information

• Product Name: MPP+ IODIDE
• Synonyms: 1-methyl-4-phenyl-pyridiniuiodide;MPP+ IODIDE (ACTIVE METABOLITE OF DOPAMI NERGIC NEUROTOX;4-phenylpyridin-1-ium iodide;N-Methyl-4-phenylpyridinium iodide;Pyridinium, 1-methyl-4-phenyl-, iodide;MPP+ iodide,1-Methyl-4-phenylpyridinium iodide;1-Methyl-4-phenylpyridin-1-iuM iodide
• CAS NO: 36913-39-0
• Molecular Formula: C₁₂H₁₂N*I
• Molecular Weight: 297.13485
• Product Categories: Aromatics;Heterocycles;Mutagenesis Research Chemicals;Neurochemicals
• Mol File: 36913-39-0.mol

Chemical Properties

• Melting Point: 166-168 °C
• Boiling Point: 281 °C at 760 mmHg
• Flash Point: 111.1 °C
• Appearance: yellow/solid
• Vapor Pressure: 0.00623mmHg at 25°C
• Storage Temp.: desiccated
• Solubility: 0.1 M HCl: soluble
• CAS DataBase Reference: MPP+ IODIDE(CAS DataBase Reference)
• NIST Chemistry Reference: MPP+ IODIDE(36913-39-0)
• EPA Substance Registry System: MPP+ IODIDE(36913-39-0)

Safety Data

• Hazard Codes: T
• Statements: 23/24/25-36/37/38-25
• Safety Statements: 26-36-45
• RIDADR: UN 2811 6.1/PG 2
• WGK Germany: 3
• RTECS: UU6580000
• Hazardous Substances Data: 36913-39-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
MPP+ IODIDE is used as a dopaminergic neurotoxin for its selective cytostatic action in small-cell lung cancer cell lines with neuroendocrine properties. It is valuable in the study and development of treatments for neuroendocrine cancers.
Used in Neurological Research:
MPP+ IODIDE is used as a neurotoxin in the research of Parkinson's disease and other neurodegenerative disorders. Its ability to induce neurotoxicity and apoptosis in animal models makes it a useful tool for understanding the underlying mechanisms of these diseases and for testing potential therapeutic interventions.
Used in Cellular and Molecular Biology:
MPP+ IODIDE is used as a research tool to study the effects of mitochondrial dysfunction, oxidative stress, and nitric oxide production on neuronal cells. Its ability to modulate dopamine distribution and activate neuronal nitric oxide synthase (nNOS) provides insights into the complex interactions between these factors and their role in neurodegenerative processes.

Biochem/physiol Actions

MPP+ iodide is an active metabolite of dopaminergic neurotoxin MPTP.

InChI:InChI=1/C11H9N.HI/c1-2-4-10(5-3-1)11-6-8-12-9-7-11;/h1-9H;1H

Upstream product

• 553-26-4 4,4'-bipyridine 
• 74-88-4 methyl iodide 
• 28289-54-5 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine 
• 960-16-7 tributylphenylstannane 
• 2589-28-8 4-bromo-N-methylpyridinium iodide 
• 95969-40-7 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine N-oxide 
• 939-23-1 p-phenylpyridine 

Downstream Products

• 107335-22-8 1-methyl-4-phenyl-1,4-dihydro-pyridine 
• 14741-34-5 tricarbonyl bis(triphenylphosphine) iron 
• 28289-54-5 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine 
• 121289-52-9 4-phenyl-N-methyl-pyridinium tetracarbonylcobaltate 
• 939-23-1 p-phenylpyridine 
• 2065-66-9 methyl-triphenylphosphonium iodide 
• 85304-48-9 1-methyl-4-phenylpyridinyl radical 
• 14965-45-8 2-methyl-1,2,3,6-tetrahydro-pyridine 
• 127382-80-3 6-methyl-1,2,3,6-tetrahydropyridine 
• 127382-75-6 1,2-dimethyl-4-phenylpyridinium iodide 

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