36929-35-8

Usage

Molecular weight

137.18 g/mol The mass of one mole of the compound, which is the total mass of all the atoms in the molecular formula.

Physical state

Colorless liquid The compound appears as a colorless liquid under normal conditions, which means it does not have a visible color and flows like a liquid.

Odor

Faint The compound has a very subtle and weak smell, which may be difficult to detect without proper equipment or in high concentrations.

Usage

Intermediate in the synthesis of pharmaceuticals and other organic compounds This chemical is primarily used as a building block or precursor in the creation of various drugs and other organic substances.

Structural feature

Spiro ring structure The compound has a unique arrangement of its atoms, with a central ring connected to another ring at two adjacent points, giving it a twisted or spiral shape.

Potential applications

Various industrial processes Due to its unique structure and properties, the compound may have a range of applications in different industries, such as the production of pharmaceuticals, agrochemicals, or other specialty chemicals.

Safety concerns

Harmful effects if not properly managed It is crucial to handle 1-Oxaspiro[2.4]heptane-2-carbonitrile(6CI,9CI) with care, as it may pose health risks or cause environmental damage if not stored, used, or disposed of correctly.

Upstream product

• 107-14-2 chloroacetonitrile 
• 120-92-3 cyclopentanone 

Downstream Products

• 124650-85-7 (1-Hydroxy-cyclopentyl)-phenylselanyl-acetonitrile 
• 124650-86-8 (1-Hydroxy-cyclopentyl)-phenyltellanyl-acetonitrile 
• 79205-55-3 (1-fluoro-cyclopentyl)-hydroxy-acetonitrile 

Relevant academic research and scientific papers

NOUVELLE VOIE DE SYNTHESE D'ACIDES AMINES MONOFLUORES

Ring opening of the glycidonitriles (IIa-e) by HF/pyridine leads to the fluorocyanohydrins (IIIa-e).Treatment of the nitriles (IIIa-e) with ammonia in methanol gives the α-amino-β-fluoro nitriles (IVa-e) which upon acidic hydrolysis afford the β-fluoro-α-

ALPHA-HYDROXY-BETA-AZIDO-TETRAZOLES

Alpha-hydroxy-beta-azido tetrazole compounds of formula (I): a process for manufacturing alpha-hydroxy-beta-azido tetrazoles of formula (I), and their use for synthesizing new compounds, e.g. in “click” chemistry.

GPR119 Agonists

GPR119 agonist compounds of the formula: and pharmaceutical compositions for the treatment of diabetes and obesity.

Expedient synthesis of glycidonitriles by darzens condensation of α-halogenonitriles with aldehydes and ketones

Chloroacetonitrile (1), α-halogenopropionitriles 4, and α-chlorophenylacetonitrile (6) react with aldehydes 2a,b,h-o and ketones 2c-g,p-t in the presence of solid NaOH in THF or DME, without any added catalyst, affording substituted glycidonitriles 3a-t, 5a, c-g,r,s and 7a,b,i,j,u,v, respectively (Darzens condensation). The glycidonitriles 3a-h, prepared from 1 and carbonyl compounds 2a-h, are obtained in high yields, exceeding those reported in the literature (Table 5). Expedient results of the reactions studied are due to increased reactivity of anions with Na+ as counterion in ethereal solvents. Investigation of the concentration of NaOH and the carbanion of diphenylacetonitrile in selected solvents reveals that ethereal solvents may increase the solubility of the anions participating in Darzens condensation.

Insertion of metallated epoxynitriles into organozirconocene chlorides. A convergent synthesis of 2-cyano-1,3-dienes

Lithiated epoxynitriles insert efficiently into alkenyizirconocene chlorides via a 1,2-metallate rearrangement to form intermediates which eliminate Cp2Zr(Cl)O- to afford substituted 2-cyano-1,3-dienes. (C) 2000 Elsevier Science Ltd.

NEW SYNTHETIC ROUTES TO β-FLUORO β-PHENYLLACTIC ACID DERIVATIVES AND Β-FLUOROCYANOHYDRINS

Alkyl phenyl 2,3-epoxycarboxylates from the well-known Darzens glycidic esters synthesis react under very mild conditions with pyridinium-poly-hydrogen fluoride to give corresponding 3-fluoro 3-phenyllactates in almost quantitative yields with a high regio and stereoselectivity.This method can be applied succesfully to other flycidic derivatives: glycidoamides, glycidonitriles, glycidoiminoesters...The spectrometric properties (IR, NMR) are presented.