36934-10-8

Upstream product

• 785-80-8 p-nitrobenzylideneaniline 
• 13716-45-5 diethyl trimethylsilyl phosphite 
• 762-04-9 Diethyl phosphonate 
• 555-16-8 4-nitrobenzaldehdye 
• 62-53-3 aniline 
• 762-04-9 phosphonic acid diethyl ester 
• 5676-82-4 (3-nitrobenzylidene)aniline 
• 122-52-1 triethyl phosphite 
• 1776-87-0 diethyl (hydroxy(4-nitrophenyl)methyl)phosphonate 
• 78-40-0 triethyl phosphate 
• 622-37-7 Phenyl azide 
• 99-61-6 3-nitro-benzaldehyde 

Relevant academic research and scientific papers

Niobium pentoxide, a recyclable heterogeneous solid surface catalyst for the synthesis of α-amino phosphonates

Abstract: Niobium pentoxide, a bifunctional solid surface catalyst, has been successfully employed to facilitate the three-component reaction between aldehydes, amines and triethyl phosphite at room temperature under solvent-free conditions to generate α-amino phosphonate in moderate to good yields. The catalyst can be recycled through simple filtration and reused to effect this transformation. Graphic abstract: [Figure not available: see fulltext.].

Magnetic ZnO?CuO?Iron ore nanocomposites as a green and highly efficient heterogeneous nanocatalyst for solventless synthesis of α-aminophosphonates

A green novel synthesis of ZnO?CuO?Iron ore nanocomposites as a novel and magnetic heterogeneous nanocatalyst is used for the one-pot synthesis of α-aminophosphonates under solventless conditions. This study benefits from the magnetic iron ore acting as a multi-mineral Lewis acid system, the green properties and the large surface area due to its nanostructure. Moreover, scanning electron microscope analysis confirmed that the nanocatalyst gave an excellent yield and good recyclability; which, even after the 10th cycle of the model reaction retained its potential with no significant loss of catalytic activity.

Catalyst free one-pot synthesis of α-aminophosphonates in aqueous ethyl lactate

An highly efficient and environmentally friendly process for the synthesis of α-aminophosphonates has been devised, through a one-pot three-component condensation of various aldehydes, amines and triethyl phosphate in water-ethyl lactate under ultrasonic

Reusable zinc oxide nanoflowers for the synthesis of α-aminophosphonates under solvent-free ultrasonication

A simple wet chemical method is used to prepare zinc oxide nanoflowers (ZnO NFs) which were subjected to various characterization techniques such as XRD, FTIR, UV–Vis, FE-SEM, and XPS. XRD pattern indicates pure, crystalline, and monodispersed form with hexagonal wurtzite phase. The 3-D flower shape morphology with hexagonal ZnO nanorods was confirmed in FE-SEM. The synthesized ZnO NFs was used to study catalytic behavior in Kabachnik–Fields reaction under controlled ultrasound cavitation technique. High surface-to-volume ratio of ZnO NFs and the effect of ultrasonication enhances the yield of α-aminophosphonate. The catalyst was recycled and reused four times without any significant loss of its catalytic activity. Moreover, existing method becomes attractive and practical due to its easy, clean, fast, cost-effective, and eco-friendly procedure.

SO 3H -functionalized magnetic Fe 3O 4 nanoparticles as an efficient and reusable catalyst for one-pot synthesis of α -amino phosphonates

Abstract: Nanomagnetic Fe 3O 4@ SiO 2-SO 3H (SO 3H-MNPs) was prepared via grafting sulfonic acid on the silica-coated Fe 3O 4 magnetite nanoparticles (MNPs). The catalytic activi

Sulfated polyborate catalyzed Kabachnik-Fields reaction: An efficient and eco-friendly protocol for synthesis of α-amino phosphonates

An efficient, and environmentally benign protocol for a three-component Kabachnik-Fields reaction of aldehydes, amines, and diethyl phosphite catalyzed by sulfated polyborate has been described to afford α-amino phosphonates under solvent-free reaction conditions. The major advantages of the present method are high yields, short reaction time, simple work-up procedure, inexpensive, eco-friendly and reusable catalyst and solvent-free reaction conditions and tolerance towards various functional groups present in the substrates.

Promiscuous lipase catalyzed a new P–C bond formation: Green and efficient protocol for one-pot synthesis of α-aminophosphonates

α-Aminophosphonates are valuable substructures with important biological and pharmacological properties. Lipase catalytic promiscuity is a new method in the organic synthesis for the preparation of α-aminophosphonates via multicomponent reaction in one pot. This efficient, simple, and eco-friendly method proceeds in the presence of immobilized Candida Antarctica lipase as catalyst under solvent-free conditions at room temperature. The new α-aminophosphonates are synthesized in high yields (up to 96%). Moreover, enzymatic-catalyzed P–C bond formation through a Kabachnik-Fields reaction was achieved for the first time.

A green one-pot three-component synthesis of α-aminophosphonates under solvent-free conditions and ultrasonic irradiation using Fe3O4@SiO2-imid-PMAn as magnetic catalyst

An efficient and environment friendly process for the synthesis of α-aminophosphonates has been devised. Through a one-pot three-component condensation of various aldehydes, amines, and triethyl phosphite in the presence of Fe3O4@SiO2-imid-PMAn nanoparticles as magnetic catalysts under solvent-free conditions and ultrasonic irradiation, α-aminophosphonates were obtained with excellent yields. The reactions under solvent-free conditions at room temperature are compared with the ultrasonic-assisted reactions. This new procedure has notable advantages such as short reaction time, excellent yields, easy purification, and the absence of any tedious workup or purification. The aforementioned catalyst could be easily recovered by an external magnetic field and can be reused for six consecutive reaction cycles without significant loss of activity. In addition, SEM and DLS of the catalyst after the reaction cycle were investigated.

Supported sulfonic acid on magnetic nanoparticles used as a reusable catalyst for rapid synthesis of α-aminophosphonates

Sulfonic acid was anchored on the surface of silica-coated cobalt ferrite core to obtain a new magnetically separable catalyst. The resultant composite was characterized by various techniques, including FT-IR, X-ray diffraction, FESEM, energy-dispersive X-ray, TEM, TGA, and vibrating sample magnetometer. The immobilized sulfonic acid was shown to be an efficient heterogeneous catalyst for the synthesis of a-aminophosphonates under solvent-free conditions at room temperature. The catalyst is readily recovered by simple magnetic decantation and can be recycled 7 times with no significant loss of catalytic activity.

Synthesis of α-aminophosphonates using carbon nanotube supported imidazolium salt-based ionic liquid as a novel and environmentally benign catalyst

A supported acidic catalyst was easily prepared via anchoring imidazolium salt-based ionic liquid onto multiwalled carbon nanotube by covalent bonds. This novel immobilized acidic ionic liquid effectively catalyzed the one-pot synthesis of α-aminophosphonates from the reaction of amines and aldehydes with diethyl phosphite. The catalyst can be easily recovered and reused without appreciable change in its efficiency.