369363-27-9Relevant academic research and scientific papers
Iminomalonate as a convenient electrophilic amination reagent for grignard reagents
Niwa, Yasuki,Takayama, Kazuki,Shimizu, Makoto
, p. 1819 - 1825 (2007/10/03)
Diethyl 2-[N-(p-methoxyphenyl)imino]malonate underwent amination reactions with alkyl Grignard reagents to give N-aklylation products in good yields. The obtained N-alkylation products were readily converted into N-alkyl-panisidines by the oxidative removal of the malonate moiety. The p-methoxyphenyl group was subsequently deprotected to give primary amines.
Electrophilic amination with iminomalonate
Niwa, Yasuki,Takayama, Kazuki,Shimizu, Makoto
, p. 5473 - 5476 (2007/10/03)
Diethyl N-anisyliminomalonate has been found to be an excellent electrophilic amination reagent for Grignard reagents to give N-alkylated products in good yields, and subsequent air oxidation affords N-alkylanisidines.
