369376-68-1

Upstream product

• 35783-10-9 benzo-1-oxepan-3-one 
• 90-02-8 salicylaldehyde 
• 29978-83-4 o-propargyloxybenzaldehyde 
• 639820-74-9 ethyl (2-vinylphenoxy)acetate 
• 63600-35-1 2-acetoxystyrene 
• 89-95-2 2-methyl-benzyl alcohol 
• 13605-66-8 1-chloro-3-(triphenylphosphoranylidene)acetone 

Relevant academic research and scientific papers

Efficient entry to 1-benzoxepine ring skeleton via tandem SN2/Wittig reaction. Total synthesis of NADH: Ubiquinone oxidoreductase (complex I) antagonist pterulinic acid

Concise synthesis of NADH: ubiquinone oxidoreductase (complex I) antagonist pterulinic acid (1a) is reported. The key architectural framework in the natural product, 1-benzoxepine ring skeleton, was smoothly prepared from known salicylaldehyde 2g and phos

Synthesis of the antifungal 1-benzoxepin pterulone

The chlorinated 1-benzoxepin derivative pterulone (1a), a potent antifungal metabolite isolated from a Pterula species, was synthesised from 4,5-dihydro-2H-benzoxepin-3-one 6 by the oxidation of 6 to 3(2H)-oxepinone 7, a Wittig reaction that transformed the keto functionality of 7 to a chlorovinyl group, and a Friedel Craft's acetylation. The mixture of E and Z isomers (1a and 1b) obtained could transformed to pure pterulone (1a) by photochemical isomerisation and separation by chromatography. The yield was 23% starting from 6.

Gold-catalyzed tandem intramolecular heterocyclization/petasis-ferrier rearrangement of 2-(Prop-2-ynyloxy)benzaldehydes as an expedient route to benzo[b]oxepin-3(2a H)-ones

The golden ring: A synthetic approach to benzo[b]oxepin-3(2a H)-ones by heterocyclization/Petasis-Ferrier rearrangement of 2-(prop-2-ynyloxy) benzaldehydes is reported. Uniquely, the ring formation was found to only proceed efficiently in the presence of

Fungicidal 1-benzoxepin derivatives

The invention concerns novel 1-benzoxepin derivatives, methods for preparing them, their use as fungicides, in particular in the form of fungicidal compositions, as well as methods for controlling phytopathogenic fungi of crops using said compounds or said compositions.

Construction of medium-ring oxacycloalkenones. Extension towards benzo-fused cyclic ethers

A study was done on the construction of medium-ring oxacycloalkenones. The synthetic protocol consisted of the intramolecular Kulinlovich cyclopropanation on oxa-esters bearing a terminal double bond, followed by oxidative cleavage of the cyclopropanol mo