36950-96-6Relevant academic research and scientific papers
Electrosynthesis of 2-arylpropionic acids from α-methylbenzyl chlorides and carbon dioxide by [Co(Salen)]
Damodar,Krishna Mohan,Khaja Lateef,Jayarama Reddy
, p. 1143 - 1150 (2007/10/03)
The electrochemical synthesis of the 2-arylpropionic acid group of nonsteroidal anti-inflammatory agents such as ibuprofen, naproxen, indoprofen, biprofen, cicloprofen, and fenoprofen has been carried out in dimethylformamide (DMF) containing tetra-n-butylammonium perchlorate (nBu4NClO 4) by electrochemical carboxylation of α-methylbenzyl chlorides catalyzed by a schiff-base complex [Co(salen)] in an undivided cell equipped with a platinum cathode and magnesium anode under constant current density of 10 mA/cm2 in good yields. Cyclic voltammetric studies have also been carried out to investigate the mechanism by which [Co(salen)] catalyzes the cathodic reaction of α-methylbenzyl chlorides in presence of CO 2 by taking α-phenylethylchloride as the model compound. Copyright Taylor & Francis, Inc.
Synthesis of α,α-disubstituted acetic acids using low-valent titanium
Garcia, Mariano,Campo, Carmen del,Llama, Emilio F.,Sinisterra, Jose V.
, p. 1771 - 1774 (2007/10/02)
Digalogenocarbenes generated using low-valent titanium (LVT) undergo a one-pot cycloaddition to diaryl, aryl alkyl or dialkyl ketones to give α,α-disubstituted acetic acids such as (R,S)-2-arylpropanoic acids.TiI4 proved most effective in this reaction for which the product yield was optimized by use of an excess of reducing agent.
Derivatives of antiphlogistically effective carboxylic acids, their preparation and medicinal use
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, (2008/06/13)
Compounds of Formula I STR1 wherein R1 is the residue of an antiphlogistically effective carboxylic acid of the formula R1 COOH, n is an integer 1, 2, or 3, and X is oxygen, sulfur, or optionally alkylated nitrogen have valuable antiinflammatory activity.
Method of using fluorene-2-acetic acid derivatives
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, (2008/06/13)
Novel fluorene-2-acetic acid derivatives and methods for preparing these derivatives are provided. Inflammatory conditions may be treated by administering these novel compounds. Additionally, it has been found that the treatment of inflammatory conditions is a new use for certain known compounds; specifically, fluorene-2-acetic acid and its 7-halo, 7-amino, and 7-nitro derivatives.
