36953-41-0

Basic information

• Product Name: 3-Bromo-4-hydroxypyridine
• Synonyms: 3-BROMO-4-HYDROXYPYRIDINE;3-BROMO-4-PYRIDINOL;4-HYDROXY-3-BROMOPYRIDINE;3-BROMO-4-HYDROXYPYRIDINE 97%;3-Bromopyridin-4-ol;Synthesis of 3-bromopyridin-4-ol
• CAS NO: 36953-41-0
• Molecular Formula: C₅H₄BrNO
• Molecular Weight: 174
• Product Categories: Pyridine;Pyridines
• Mol File: 36953-41-0.mol
• Article Data: 6

Chemical Properties

• Melting Point: 225-230℃
• Boiling Point: 244.3 °C at 760 mmHg
• Flash Point: 101.6 °C
• Appearance: /
• Density: 1.776 g/cm³
• Vapor Pressure: 0.0306mmHg at 25°C
• Refractive Index: 1.6
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 3.71±0.18(Predicted)
• CAS DataBase Reference: 3-Bromo-4-hydroxypyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Bromo-4-hydroxypyridine(36953-41-0)
• EPA Substance Registry System: 3-Bromo-4-hydroxypyridine(36953-41-0)

Safety Data

• Hazardous Substances Data: 36953-41-0(Hazardous Substances Data)

Usage

General Description

3-Bromo-4-hydroxypyridine is a chemical compound with the molecular formula C5H4BrNO, and it is classified as a halogenated pyridine derivative. It is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and organic compounds. 3-Bromo-4-hydroxypyridine is known for its versatile reactivity, and it serves as a valuable building block for the preparation of various functionalized pyridines. Its unique structure and properties make it a valuable tool in organic synthesis and medicinal chemistry. Additionally, 3-Bromo-4-hydroxypyridine has been studied for its potential biological activities, including antifungal and antibacterial properties, making it an important target for further research and development.

InChI:InChI=1/C5H4BrNO/c6-4-3-7-2-1-5(4)8/h1-3H,(H,7,8)

Upstream product

• 25813-25-6 3,5-dibromo-4-hydroxypyridine 
• 504-24-5 4-aminopyridine 
• 13534-98-0 3-bromopyridin-4-amine 
• 626-64-2 pyridin-4-ol 
• 1124-33-0 4-nitraminopyridine N-oxide 

Downstream Products

• 1214377-46-4 3-bromo-4-(difluoromethoxy)pyridine 
• 868734-89-8 4-(2-fluoro-4-aminophenoxyl)-3,3'-bipyridine 

Relevant articles and documents

Preparation method of pyridine derivative (by machine translation)

To the method, piperidine-4-one hydrochloride is used as a raw material, and a series of pyridine derivatives are obtained through halogenation reaction and elimination reaction. The reaction is eliminated by reacting piperidine-4-one hydrochloride with a specific amount of the 3,5 - halogenating agent in a halogenation 3, 3, 5 - reaction with a halogen-3, 3, 5, 5 - based reaction, followed by reaction with a pyridine derivative of a hydroxyl group, an amino group 4 - or a dimethylamino group, respectively, by eliminating the reaction with a different kind of basic agent. The method is simple and convenient to operate, mild in condition, short in technological process, low in waste water yield, environment-friendly, low in cost and beneficial to green industrial production of the pyridine derivative. (by machine translation)

ALDOSTERONE SYNTHASE INHIBITORS

This invention relates to tricyclic triazole analogues of the formula I or their pharmaceutically acceptable salts, wherein the variable are defined herein. The inventive compounds selectively inhibit aldosterone synthetase. This invention also provides for pharmaceutical compositions comprising the compounds of Formula I or their salts as well as to methods for the treatment, amelioration or prevention of conditions that could be treated by inhibiting aldosterone synthetase.

Efficient regioselective preparation of monobromo and bromoiodo hydroxy pyridines from dibromoderivatives via bromine-lithium exchange

Annular dibromination of hydroxypyridines with NBS in acetonitrile followed by bromine-lithium exchange with RLi and subsequent trapping with H2O or I2 afforded monobromo and bromoiodo derivatives in a completely regioselective way. Iodination of bromo hydroxypyridines with NIS is totally regioselective.