868734-88-7

Basic information

• Product Name: 4-(2-fluoro-4-nitrophenoxyl)-3,3'-bipyridine
• Synonyms: 4-(2-fluoro-4-nitrophenoxyl)-3,3'-bipyridine
• CAS NO: 868734-88-7
• Molecular Weight: 311.272
• Mol File: 868734-88-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(2-fluoro-4-nitrophenoxyl)-3,3'-bipyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-fluoro-4-nitrophenoxyl)-3,3'-bipyridine(868734-88-7)
• EPA Substance Registry System: 4-(2-fluoro-4-nitrophenoxyl)-3,3'-bipyridine(868734-88-7)

Safety Data

• Hazardous Substances Data: 868734-88-7(Hazardous Substances Data)

Upstream product

• 504-24-5 4-aminopyridine 
• 626-55-1 3-Bromopyridine 
• 13534-98-0 3-bromopyridin-4-amine 
• 36953-41-0 3-bromo-4-hydroxypyridine 

Downstream Products

• 868734-89-8 4-(2-fluoro-4-aminophenoxyl)-3,3'-bipyridine 

Relevant articles and documents

Synthesis and biological evaluation of 4-(2-fluorophenoxy)-3,3′-bipyridine derivatives as potential c-met inhibitors

Six series of novel 4-(2-fluorophenoxy)-3,3′-bipyridine derivatives conjugated with aza-aryl formamide/amine scaffords were designed and synthesized through a structure-based molecular hybridization approach. The target compounds were evaluated for c-Met kinase inhibitory activities and cytotoxicity against four cancer cell lines (HT-29, A549, MKN-45 and MDA-MB-231) in vitro. Most compounds exhibited moderate to excellent potency, and the most promising candidate 26c (c-Met kinase IC50 = 8.2 nM) showed a 4.7-fold increase in cytotoxicity against c-Met-addicted MKN-45 cell line in vitro (IC50 = 3 nM), superior to that of Foretinib (IC50 = 23 nM). The preliminary structure-activity relationship indicated that a 1H-benzo [e] [1,3,4]thiadiazine-3-carboxamide-4,4-dioxide moiety as linker contributed to the antitumor potency.