36958-20-0Relevant academic research and scientific papers
Highly efficient asymmetric mannich reaction of dialkyl α-diazomethylphosphonates with N -carbamoyl imines catalyzed by chiral bronsted acids
Zhang, Hui,Wen, Xiaojing,Gan, Lihua,Peng, Yungui
, p. 2126 - 2129 (2012/07/17)
An efficient method involving the first use of chiral phosphoric acids as catalysts in the asymmetric Mannich reaction of dialkyl diazomethylphosphonates and N-carbamoyl imines is developed. With only 0.1 mol % catalyst 1f, the reaction proceeded smoothly and produced the corresponding β-amino-α- diazophosphonate with up to 97% yield and >99% ee.
