96914-74-8Relevant academic research and scientific papers
Highly efficient asymmetric mannich reaction of dialkyl α-diazomethylphosphonates with N -carbamoyl imines catalyzed by chiral bronsted acids
Zhang, Hui,Wen, Xiaojing,Gan, Lihua,Peng, Yungui
supporting information; experimental part, p. 2126 - 2129 (2012/07/17)
An efficient method involving the first use of chiral phosphoric acids as catalysts in the asymmetric Mannich reaction of dialkyl diazomethylphosphonates and N-carbamoyl imines is developed. With only 0.1 mol % catalyst 1f, the reaction proceeded smoothly and produced the corresponding β-amino-α- diazophosphonate with up to 97% yield and >99% ee.
Synthesis and biological evaluation of phosphonamidate peptide inhibitors of enkephalinase and angiotensin-converting enzyme
Elliott,Marks,Berg,Portoghese
, p. 1208 - 1216 (2007/10/02)
The effectiveness of phosphonamidate peptide analogues as inhibitors of rat kidney or human brain metallo-endopeptidase (enkephalinase, E.C. 3.4.24.11) and angiotensin-converting enzyme (ACE, 3.4.15.1) has been explored with a series of enkephalin analogu
