3696-53-5Relevant academic research and scientific papers
Different modes of acid-catalyzed cyclization of 4-(γ-oxoalkyl)semicarbazide hydrazones: 7-membered versus 14-membered cyclic semicarbazones formation
Fesenko, Anastasia A.,Shutalev, Anatoly D.
, p. 9528 - 9543 (2015/12/05)
Acid-catalyzed cyclization of 4-(γ-oxoalkyl)semicarbazide hydrazones has been studied. 7-Membered cyclic semicarbazones, 2,4,5,6-tetrahydro-3H-1,2,4-triazepin-3-ones, were obtained from the γ-phenyl-substituted semicarbazides, while the cyclization of the γ-methyl-substituted semicarbazides involved two molecules of the starting material to result in 14-membered cyclic bis-semicarbazones, 1,2,4,8,9,11-hexaazacyclotetradeca-7,14-diene-3,10-diones. The 4-(γ-oxoalkyl)semicarbazide hydrazones were prepared according to a four-step synthesis based on amidoalkylation of the sodium enolates of 1,3-diketones with ethyl N-(1-tosylalk-1-yl)carbamates followed by base-promoted retro-Claisen reaction and treatment of the obtained ethyl N-(γ-oxoalkyl)carbamates with hydrazine.
Highly enantioselective monofluoromethylation of C2-arylindoles using FBSM under chiral phase-transfer catalysis
Matsuzaki, Kohei,Furukawa, Tatsuya,Tokunaga, Etsuko,Matsumoto, Takashi,Shiro, Motoo,Shibata, Norio
supporting information, p. 3282 - 3285 (2013/07/26)
The highly enantioselective addition of 1-fluoro-1,1-bis(phenylsulfonyl) methane (FBSM) to vinylogous imines generated in situ from 2-aryl-3-(1- arylsulfonylmethyl)indoles was achieved using chiral ammonium salts derived from cinchona alkaloids. One-pot c
InBr3: A versatile catalyst for the different types of Friedel-Crafts reactions
Thirupathi, Ponnaboina,Sung, Soo Kim
supporting information; experimental part, p. 7755 - 7761 (2009/12/27)
(Chemical Equation Presented) Mild and efficient InBr3-catalyzed Friedel-Crafts alkylation of heteroaromatic or electron-rich aromatic compounds with α-amido sulfones at room temperature in CH2Cl2 has been developed. The p
