369656-38-2

Upstream product

• 1477803-40-9 C₁₃H₁₅N₃O₂ 
• 24424-99-5 di-tert-butyl dicarbonate 
• 675137-08-3 Methyl 4-{[(tert-butoxycarbonyl)(1H-imidazol-2-ylmethyl)amino]methyl}benzoate 
• 509090-93-1 C₁₂H₁₃N₃O₂ 
• 2417-72-3 Methyl 4-(bromomethyl)benzoate 
• 10111-08-7 2-imidazolecarbaldehyde 

Downstream Products

• 675137-31-2 N-(4-dipropylaminomethylphenyl)-4-{[N-boc-N-(1H-imidazol-2-ylmethyl)amino]methyl}-benzamide 
• 675137-86-7 [4-(4-{[boc-(1H-imidazol-2-ylmethyl)amino]methyl}benzoylamino)benzyl]cyclohexylcarbamic acid benzyl ester 
• 675138-00-8 {4-[4-(cyclohexyl-methylamino)-butylcarbamoyl]-benzyl}-(1H-imidazol-2-ylmethyl)-carbamic acid t-butyl ester 
• 675136-51-3 [4-(4-dipropylamino-butylcarbamoyl)-benzyl]-(1H-imidazol-2-ylmethyl)-carbamic acid t-butyl ester 
• 369656-39-3 4-(1H-imidazol-2-ylmethylaminomethyl)-benzoic acid methyl ester 
• 675137-08-3 Methyl 4-{[(tert-butoxycarbonyl)(1H-imidazol-2-ylmethyl)amino]methyl}benzoate 
• 369656-66-6 (S)-2-(4-((N-Boc-N-imidazol-2-ylmethyl) aminomethyl) benzoyl) amino-5-phthalimide valerate (1'S)-1'-(1-naphthyl)ethylamide 
• 370595-04-3 Nα-4-(N-Boc-N-(imidazol-2-ylmethyl)aminomethyl)benzoyl-NG-Pmc-L-arginine (1'S)-1'-(1-naphthyl) ethylamide 
• 1259418-56-8 C₂₈H₄₅N₅O₃ 
• 369656-41-7 4-{[t-butoxycarbonyl-(1-methyl-1H-imidazol-2-ylmethyl)-amino]-methyl}-benzoic acid methyl ester 
• 509091-10-5 N-(1-naphthylmethyl)-5-phthalimide-(S)-2-[4-[N-Boc-N-(imidazol-2-ylmethyl)aminomethyl]benzoylamino]pentanoylamide 
• 509091-12-7 N-[(1S)-1-(1-naphthyl)ethyl]-4-(methoxycarbonyl)-2-(S)-[4-[N-Boc-N-(imidazol-2-ylmethyl)aminomethyl]benzoylamino]butyrylamide 

Relevant academic research and scientific papers

COMPOUND HAVING ACIDIC GROUP WHICH MAY BE PROTECTED, AND USE THEREOF

A compound represented by general formula (I): a salt thereof, a solvate thereof, or a prodrug thereof wherein all symbols are as defined in the specification. The compound of the present invention has antagonistic activity against CXCR4 and is therefore

BASIC AMINE COMPOUND AND USE THEREOF

Novel amine compounds which are represented by the following formula (1) and efficacious against diseases such as a viral infectious disease with HIV, rheumatism, and cancer metastasis; typically, A 1 and A 2 represent a hydrogen atom or a substitutable monocyclic or polycyclic heteroaromatic ring and W represents a substitutable benzene ring or any group represented by the following formula (10) or (11): where X represents O, CH 2 , C(=O), NR 11 , or CHR 35 and D represents a group represented by the following formula (6): where Q represents a single bond, NR 12 , or a group represented by the formula (13): and Y represents a group represented by the following formula (7) : where z represents a substitutable monocyclic or polycyclic aromatic ring; and B represents -NR 25 R 26 ; and R 1 to R 26 in the above formulae represent a hydrogen atom, an alkyl group, an alkenyl group, or an alkynyl group.

AMINE COMPOUNDS AND USE THEREOF

It is intended to provide novel amine compounds which are efficacious against diseases such as infection with HIV virus, rheumatism and cancer metastasis. Namely, amine compounds represented by the following general formula (1):In a typical case, A1 and A2 represent each an optionally substituted monocyclic or polycyclic aromatic heterocycle; W represents cyclic C3-10 alkylene, an optionally substituted monocyclic or polycyclic aromatic heterocycle, a monocyclic or polycyclic aromatic ring or a partly saturated polycyclic aromatic ring; X represents O, CH2, C(=O) or NR11; and D is a group represented by the following general formula (4) or (6).-Q-Y-BIn the formula (6), Q represents a single bond, S, O or NR12; and Y is a group represented by the following general formula (7). z represents an optionally substituted monocyclic or polycyclic aromatic ring. In the formula (6), B represents NR25R26. In the above formulae, R1 to R26 each represents hydrogen, alkyl, alkenyl or alkynyl.

CXCR4-ANTAGONISTIC DRUGS COMPRISING NITROGEN-CONTAINING COMPOUND

To provide novel nitrogen-containing compounds having antagonism to CXCR4 and remedies for disease, such as rheumatism, cancer metastasis, etc., based on the CXCR4 antagonism. Nitrogen-containing compounds represented by the following general formula and

NOVEL NITROGENOUS COMPOUND AND USE THEREOF

A novel nitrogen-containing compound effective against diseases such as HIV viral infectious diseases, rheumatism, and cancerous metastasis. It is a nitrogen-containing compound represented by the following general formula (1). In the formula, A typically represents a group represented by the formula (2) (A1 is hydrogen or an optionally substituted, mono- or polycyclic, heteroaromatic or aromatic ring; G1 is a single bond or a hydrocarbon group represented by the following formula (3) wherein R1, R2, and R3 may be optionally substituted hydrocarbon groups); W is an optionally substituted hydrocarbon group or heterocyclic ring; x is -C(=O)NH-; y is -C(=O)-; and D1 is hydrogen atom, alkyl having a polycyclic aromatic ring, di (substituted alkyl)amine, or alicyclic amine.

NITROGENOUS COMPOUNDS AND ANTIVIRAL DRUGS CONTAINING THE SAME

The present invention provides novel compounds having antiviral activities and antiviral drugs containing the compounds as the active ingredient. The compounds are shown by the following general formula (1), wherein typically A1 and A2 are each guanidine or a group of the general fomula (ia) ; A3 is a mono- or poly-cyclic heteroaromatic ring contining 1 or 2 heteroatoms ; B1 is a single bond or alkylene group; R1 is hydrogen or alkyl group; W is an alkylene having 2-3 carbons, a cycloalkylene having 5-10 carbons, aromatic ring having 6-10 carbons, or a heteroaromatic ring having 5-10 carbons; y is C(=O)-; x is -C(=O)-NH-; n1 is an integer of 1-2; n2 is an integer of 2-3; D is a substituent selected from among various groups.