36978-50-4

Basic information

• Product Name: 5-(2-METHYLPHENYL)-5-OXOVALERIC ACID
• Synonyms: 5-(2-METHYLPHENYL)-5-OXOVALERIC ACID
• CAS NO: 36978-50-4
• Molecular Formula: C₁₂H₁₄O₃
• Molecular Weight: 206.24
• Mol File: 36978-50-4.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 392.8°C at 760 mmHg
• Flash Point: 205.6°C
• Appearance: /
• Density: 1.137g/cm³
• Vapor Pressure: 7.08E-07mmHg at 25°C
• Refractive Index: 1.536
• CAS DataBase Reference: 5-(2-METHYLPHENYL)-5-OXOVALERIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(2-METHYLPHENYL)-5-OXOVALERIC ACID(36978-50-4)
• EPA Substance Registry System: 5-(2-METHYLPHENYL)-5-OXOVALERIC ACID(36978-50-4)

Safety Data

• Hazardous Substances Data: 36978-50-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H14O3/c1-9-5-2-3-6-10(9)11(13)7-4-8-12(14)15/h2-3,5-6H,4,7-8H2,1H3,(H,14,15)

Upstream product

• 33872-80-9 o-tolyl magnesium chloride 
• 53715-97-2 5,5'-oxybis(5-oxopentanoic acid) 
• 18180-77-3 (1S,2R)-trans-2-(2-methylphenyl)-1-cyclohexanol 
• 932-31-0 ortho-tolylmagnesium bromide 
• 108-55-4 glutaric anhydride, 
• 95-46-5 2-methylphenyl bromide 
• 120-92-3 cyclopentanone 
• 5205-39-0 ethyl glutaroyl chloride 
• 100972-13-2 ethyl 5-oxo-5-(2-methylphenyl)pentanoate 
• 100256-17-5 o-tolylcyclopentan-1-ol 

Downstream Products

• 100972-13-2 ethyl 5-oxo-5-(2-methylphenyl)pentanoate 
• 51015-28-2 8-Methyl-1,2,3,4-tetrahydronaphthalin-1-on 

Relevant articles and documents

Direct Synthesis of Chiral NH Lactams via Ru-Catalyzed Asymmetric Reductive Amination/Cyclization Cascade of Keto Acids/Esters

Lactams with a stereogenic center adjacent to the N atom have existed in many medicinal agents and bioactive alkaloids. Herein we report a broadly applicable synthesis of enantioenriched NH lactams through a one-pot asymmetric reductive amination/cyclization sequence of easily available keto acids/esters. Such cascade processes alleviate the demand for protecting group manipulations as well as intermediate purification. This strategy is capable of constructing enantioenriched lactams and benzo-lactams of a five-, six-, or seven-membered ring in generally high yield and with excellent enantioselectivities (up to 97% ee). Scalable and concise syntheses of key drug intermediates have further displayed the importance of this methodology.

Visible-Light-Promoted Metal-Free Aerobic Oxidation of Primary Amines to Acids and Lactones

A unique metal-free aerobic oxidation of primary amines via visible light photocatalytic double carbon–carbon bonds cleavage and multi carbon–hydrogen bonds oxidation was observed. Aerobic oxidation of primary amines could be controlled to afford acids by using dioxane with 18 W CFL, and lactones by using DMF with 8 W green LEDs, respectively. A plausible mechanism was proposed based on control experiments. This observation showed direct evidences for the fragmentation in the aerobic oxidation of aliphatic primary amines.

Catalytic asymmetric hydrogenation of δ-ketoesters: Highly efficient approach to chiral 1,5-diols

High turnover: An highly efficient catalytic asymmetric hydrogenation of δ-aryl-δ-ketoesters has been realized by using the chiral spiroiridium catalyst (R)-1. Chiral 1,5-diol products are obtained with excellent enantioselectivity and turnover numbers (TONs) as high as 100 000. TOF=turnover frequency. Copyright