116153-81-2Relevant academic research and scientific papers
Pyrazole-3/5-carboxylic acids from 3/5-trifluoromethyl NH-pyrazoles
Ermolenko, Mikhail S.,Guillou, Sandrine,Janin, Yves L.
, p. 257 - 263 (2013/01/15)
We report here the transformation of 3/5-trifluoromethylpyrazoles derivative into the corresponding NH-pyrazole-3/5-carboxylic acids. Moreover, from 4- or 5-iodinated-3/5-trifluoromethylpyrazoles building blocks and the use of Suzuki-Miyaura or Negishi reactions followed by the trifluoromethyl hydrolysis, we illustrate short and original accesses to many series of NH-pyrazole-3/5-carboxylic acids otherwise difficult to prepare.
Synthesis of 3-cyanopyrazoles from 3-trifluoromethyl-pyrazoles via direct ammonolysis reaction
Yan, Tao,Chen, Yanhong,Wang, Jia,Xie, Yuyuan,Yang, Chunhao
scheme or table, p. 431 - 439 (2012/03/09)
A simple and green method to prepare 3-cyanopyrazoles in aqueous ammonia from easy-obtained 3-trifluoromethyl-pyrazoles was explored. Most substrates got acceptable yields. The hydrogen position of N1-H on cyanopyrazoles was assigned by X-ray crystal structure analysis.
