370-58-1Relevant academic research and scientific papers
(Methylsulfonyl)phenyl-2-(5H)-furanones as COX-2 inhibitors
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, (2008/06/13)
The invention encompasses the novel compound of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases. STR1 The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.
An efficient asymmetric synthesis of a potent COX-2 inhibitor L-784,512
Tan, Lushi,Chen, Cheng-Yi,Larsen, Robert D.,Verhoeven, Thomas R.,Reider, Paul J.
, p. 3961 - 3964 (2007/10/03)
An efficient enantioselective synthesis of L-784,512 featuring a Horner- Emmons reaction, a new one-pot trifluoromethylation, and the Sharpless asymmetric dihydroxylation is described.
