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2-Fluoro-4'-nitroacetanilide is an organic compound with the chemical formula C8H7FN2O3. It is a derivative of acetanilide, featuring a fluorine atom at the 2nd carbon position and a nitro group at the 4' position of the aniline part. This yellow crystalline solid is primarily used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. Due to its reactivity and potential applications, it is important to handle 2-fluoro-4'-nitroacetanilide with care, as it may have hazardous properties.

370-89-8

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370-89-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 370-89-8 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,7 and 0 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 370-89:
(5*3)+(4*7)+(3*0)+(2*8)+(1*9)=68
68 % 10 = 8
So 370-89-8 is a valid CAS Registry Number.
InChI:InChI=1/C8H7FN2O3/c9-5-8(12)10-6-1-3-7(4-2-6)11(13)14/h1-4H,5H2,(H,10,12)

370-89-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-fluoro-N-(4-nitrophenyl)acetamide

1.2 Other means of identification

Product number -
Other names 2-Fluoro-4'-nitroacetanilide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:370-89-8 SDS

370-89-8Downstream Products

370-89-8Relevant academic research and scientific papers

Silver-Promoted Fluorination Reactions of α-Bromoamides

Mizuta, Satoshi,Kitamura, Kanami,Kitagawa, Ayako,Yamaguchi, Tomoko,Ishikawa, Takeshi

supporting information, p. 5930 - 5935 (2021/02/01)

Silver-promoted C?F bond formation in α-bromoamides by using AgF under mild conditions is reported. This simple method enables access to tertiary, secondary, and primary alkyl fluorides involving biomolecular scaffolds. This transformation is applicable to primary and secondary amides and shows broad functional-group tolerance. Kinetics experiments revealed that the reaction rate increased in the order of 3°>2°>1° α-carbon atom. In addition, it was found that the acidic amide proton plays an important role in accelerating the reaction. Mechanistic studies suggested generation of an aziridinone intermediate that undergoes subsequent nucleophilic addition to form the C?F bond with stereospecificity (i.e., retention of configuration). The synthesis of sterically hindered alcohols and ethers by using AgI is also demonstrated. Examples of reactions of α-bromoamides with O nucleophiles are presented.

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