640-19-7 Usage
Description
Fluoroacetamide is an odourless, tasteless, white, crystalline water soluble. It is a fluorinated
amide and reacts with azo and diazo compounds to generate toxic gases. Flammable
gases are formed by the reaction of organic amides/imides with strong reducing agents.
Fluoroacetamide is used as a rodenticide and insecticide to control rabbits but is dangerous
for other species of pests, farm livestock, and humans. Fluoroacetamide is a noncombustible
substance itself and does not burn but may decompose upon heating to
produce irritating, corrosive, and/or toxic fumes. On decomposition, fluoroacetamide
releases nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon
dioxide, HF gas, and nitrogen gas.
Chemical Properties
Different sources of media describe the Chemical Properties of 640-19-7 differently. You can refer to the following data:
1. crystals
2. Fluoroacetamide is a colorless, crystalline
solid.
Uses
Rodenticide. Insecticide proposed mainly for use on fruits to combat scale insects, aphids, and mites.
Definition
ChEBI: Acetamide substituted at C-2 by a fluorine atom.
Production Methods
Fluoroacetamide is produced by reaction of α-chloroacetamide
with potassium fluoride in tetrachloroethylene
at elevated temperature.
General Description
Colorless crystalline powder. Used as a rodenticide. Highly toxic.
Air & Water Reactions
Very soluble in water [Farm Chemicals]
Reactivity Profile
FLUOROACETAMIDE is a fluorinated amide. Organic amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).
Hazard
Extremely toxic; poison; mutagen.
Health Hazard
FLUOROACETAMIDE is super toxic; probable oral lethal dose in humans is less than 5 mg/kg, or a taste (less than 7 drops) for a 150-lb. person. Chemically inhibits oxygen metabolism by cells with critical damage occurring to the heart, brain, and lungs resulting in heart failure, respiratory arrest, convulsions, and death.
Fire Hazard
Emits very toxic fumes of fluorine containing compounds and nitrogen oxides when heated to decomposition. Avoid decomposing heat.
Safety Profile
A human poison by an
unspecified route. Poison experimentally by
ingestion, skin contact, intraperitoneal,
subcutaneous, and intravenous routes.
Human systemic effects by unspecified
route: convulsions, coma, nausea and
vomiting. Experimental reproductive effects.
Mutation data reported. Used as an
insecticide and rodenticide. When heated to
decomposition it emits very toxic fumes of
Fand NOx. See also FLUORIDES.
Potential Exposure
This material is an organofluorine
rodenticide; insecticide proposed mainly for use on fruits to
combat scale insects, aphids, and mites. Use is largely
restricted to licensed pest control operators.
Shipping
UN2811 Toxic solids, organic, n.o.s., Hazard
Class: 6.1; Labels: 6.1-Poisonous materials, Technical
Name Required.
Purification Methods
Crystallise fluoroacetamide from chloroform and dry it in a vacuum. [Beilstein 2 IV 454.]
Waste Disposal
Consult with environmental
regulatory agencies for guidance on acceptable disposal
practices. Generators of waste containing this contaminant
(≥100 kg/mo) must conform with EPA regulations govern ing storage, transportation, treatment, and waste disposal.
Check Digit Verification of cas no
The CAS Registry Mumber 640-19-7 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,4 and 0 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 640-19:
(5*6)+(4*4)+(3*0)+(2*1)+(1*9)=57
57 % 10 = 7
So 640-19-7 is a valid CAS Registry Number.
InChI:InChI=1/C2H4FNO/c3-1-2(4)5/h1H2,(H2,4,5)
640-19-7Relevant articles and documents
Polgar et al.
, p. 421,422 (1973)
Method for preparing fluoroacetamide for quantitative and qualitative determination of forensic science
-
Paragraph 0021-0028, (2017/09/13)
The invention discloses a method for preparing fluoroacetamide for quantitative and qualitative determination of the forensic science. The method comprises the following steps: (1) dissolving fluoracyl chloride in an organic solvent, and then adding the obtained solution into a reaction kettle; (2) pumping ammonia into the reaction kettle, and performing stirring for reaction; (3) performing filtering, flushing the filter cake with an organic solvent, and merging organic phases; and (4) washing the organic phases with a saturated salt solution, performing drying, performing reduced pressure distillation to remove the organic solvent and to obtain a white solid, and performing forced air drying to obtain fluoroacetamide. The method is high in productivity, the prepared fluoroacetamide is high in purity and can directly serve as a standard substance or a reference material for use, and the demand for toxicological analysis of the forensic science in the reality is met.
Reactions of Cyclic Peroxides with Aldehydes and Ketones catalysed by Trimethylsilyl Trifluoromethanesulphonate. An Efficient Synthesis of 1,2,4-Trioxanes
Jefford, Charles W.,Boukouvalas, John,Kohmoto, Shigeo
, p. 523 - 524 (2007/10/02)
Trimethylsilyl trifluoromethanesulphonate is found to be an efficient catalyst for the reaction of 1,4-endoperoxides and 1,2-dioxetanes with aldehydes and ketones to give 1,2,4-trioxanes in high yields.
