37002-48-5 Usage
Uses
Used in Pharmaceutical Industry:
(+)-DIOP is used as a ligand for the in situ preparation of chiral hydrogenation catalysts, which are essential in the synthesis of pharmaceutical compounds with specific chiral properties. Its ability to create enantiomerically pure products is crucial in the development of single-enantiomer drugs.
Used in Chemical Synthesis:
(+)-DIOP is used as a ligand for Rh(I)-catalyzed asymmetric hydrogenation of enamides, a reaction that is vital in the synthesis of various organic compounds, including those with pharmaceutical applications.
Used in Organic Chemistry:
(+)-DIOP is employed for the 1,4-disilylation of α,β-unsaturated ketones, a reaction that allows for the formation of new carbon-carbon bonds and the creation of complex molecular structures.
Used in Heck Reaction:
(+)-DIOP is used in the Heck reaction of alkenyl iodides, a widely used method for the formation of carbon-carbon bonds in organic synthesis, leading to the production of various valuable compounds.
Used in Hydroformylation:
(+)-DIOP is utilized in the hydroformylation of olefins, a process that involves the conversion of alkenes to aldehydes, which are important intermediates in the production of various chemicals and pharmaceuticals.
Check Digit Verification of cas no
The CAS Registry Mumber 37002-48-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,7,0,0 and 2 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 37002-48:
(7*3)+(6*7)+(5*0)+(4*0)+(3*2)+(2*4)+(1*8)=85
85 % 10 = 5
So 37002-48-5 is a valid CAS Registry Number.
InChI:InChI=1/C31H32O2P2/c1-31(2)32-29(23-34(25-15-7-3-8-16-25)26-17-9-4-10-18-26)30(33-31)24-35(27-19-11-5-12-20-27)28-21-13-6-14-22-28/h3-22,29-30H,23-24H2,1-2H3/t29-,30-/m1/s1
37002-48-5Relevant academic research and scientific papers
Green, Malcolm L. H.,Walker, Neil M.
, p. 379 - 382 (1988)
The syntheses of the chiral cyclopentadiene compound (4S,5S)-trans-4-(cyclopentadiene-1-methyl)-5-diphenylphosphine-2,2-dimethyl-1,3-dioxolane (4) and of the related ferrocenylphosphine derivative trans- (5) are described.
High linear selectivity ligand for allyl alcohol hydroformylation
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Page/Page column 7; 8, (2020/11/28)
A process for selectively producing 4-hydroxybutyraldehyde from allyl alcohol is described. The process comprises reacting allyl alcohol with a mixture of carbon monoxide and hydrogen in the presence of a solvent and a catalyst system comprising a rhodium complex and a trans-1,2-bis(bis(3,4,5-tri-n-alkylphenyl)phosphinomethyl)-cyclobutane. The process gives high yield of 4-hydroxybutyraldehyde compared to temperature.
Decarboxylative aldol reactions of allyl β-keto Esters via heterobimetallic catalysis
Lou, Sha,Westbrook, John A.,Schaus, Scott E.
, p. 11440 - 11441 (2007/10/03)
Mild and selective heterobimetallic-catalyzed decarboxylative aldol reactions involving allyl β-keto esters have been developed. The reaction is promoted by Pd(0)- and Yb(III)-DIOP complexes at room temperature and involves the in situ formation of a ketone enolate from allyl β-keto esters followed by addition of the enolate to aldehydes. The reaction is a new example of heterobimetallic catalysis in which the optimized reaction conditions require the addition of both metals. Copyright
