37009-16-8

Upstream product

• 85-44-9 phthalic anhydride 

Downstream Products

• 861136-85-8 1-[3-(1-methoxy-3-methyl-5,6,7,8-tetrahydro-isoquinolin-4-ylamino)-phenyl]-ethanone 
• 861136-90-5 [3-(1-methoxy-3-methyl-5,6,7,8-tetrahydro-isoquinolin-4-ylamino)-phenyl]-methanol 
• 861136-87-0 (3-methansulfonyl-phenyl)-(1-methoxy-3-methyl-5,6,7,8-tetrahydro-isoquinolin-4-yl)-amine 
• 861136-88-1 N-[3-(1-methoxy-3-methyl-5,6,7,8-tetrahydro-isoquinolin-4-ylamino)-phenyl]-acetamide 
• 861136-86-9 3-(1-methoxy-3-methyl-5,6,7,8-tetrahydro-isoquinolin-4-ylamino)-N,N-dimethyl-benzamide 
• 861136-89-2 (1-methoxy-3-methyl-5,6,7,8-tetrahydro-isoquinolin-4-yl)-(3-trifluoromethoxy-phenyl)-amine 

Relevant academic research and scientific papers

Poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors based on a tetrahydro-1(2H)-isoquinolinone Scaffold: Synthesis, biological evaluation and X-ray crystal structure

The synthesis, activity and physical properties of two series of novel potent tetrahydro-1(2H)-isoquinolinone based PARP-1 inhibitors are described. The new structural classes with a non-planar ring system interact specifically with the PARP-1 protein at the nicotinamide-binding site. Georg Thieme Verlag Stuttgart.