861136-89-2

Upstream product

• 861136-84-7 4-bromo-1-methoxy-3-methyl-5,6,7,8-tetrahydro-isoquinoline 
• 1535-73-5 m-trifluoromethoxyaniline 
• 14380-86-0 ethyl 2-(1,3-dioxoisoindolin-2-yl)propanoate 
• 861136-82-5 4-bromo-3-methyl-5,6,7,8-tetrahydro-2H-isoquinolin-1-one 
• 37009-16-8 3-methyl-5,6,7,8-tetrahydro-2H-isoquinolin-1-one 
• 7114-80-9 3-methylisoquinolone 
• 5423-95-0 4-hydroxy-3-methyl-2H-isoquinolin-1-one 
• 85-44-9 phthalic anhydride 

Relevant academic research and scientific papers

Poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors based on a tetrahydro-1(2H)-isoquinolinone Scaffold: Synthesis, biological evaluation and X-ray crystal structure

The synthesis, activity and physical properties of two series of novel potent tetrahydro-1(2H)-isoquinolinone based PARP-1 inhibitors are described. The new structural classes with a non-planar ring system interact specifically with the PARP-1 protein at the nicotinamide-binding site. Georg Thieme Verlag Stuttgart.

SUBSTITUTED TETRAHYDRO-2H-ISOQUINOLIN-1-ONE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, AND USE OF THE SAME AS MEDICAMENTS

The invention relates to compounds of general formula (I), the designations of the substituents R1, R2, Ar and X being cited in the description, and to the physiologically compatible salts thereof. The invention also relates to a method for producing said compounds, and to the use thereof as medicaments. The inventive compounds are poly(ADP-ribose)polymerase (PARP) inhibitors.