37021-34-4

Basic information

• Product Name: 1,2,2,2-TETRACHLORO-1-FLUOROETHYL METHYL ETHER
• Synonyms: 1,2,2,2-TETRACHLORO-1-FLUOROETHYL METHYL ETHER;1,2,2,2-TETRACHLORO-1-FLUOROETHYL METHYL ETHER, 99% MIN.;2-Fluoro-2-methoxy-1,1,1,2-tetrachloroethane;Methyl 1-fluoro-1,2,2,2-tetrachloroethyl ether
• CAS NO: 37021-34-4
• Molecular Formula: C₃H₃Cl₄FO
• Molecular Weight: 215.87
• Mol File: 37021-34-4.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 57°C 18mm
• Flash Point: 46.4°C
• Appearance: /
• Density: 1.593g/cm³
• Vapor Pressure: 4.33mmHg at 25°C
• Refractive Index: 1.461
• CAS DataBase Reference: 1,2,2,2-TETRACHLORO-1-FLUOROETHYL METHYL ETHER(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,2,2-TETRACHLORO-1-FLUOROETHYL METHYL ETHER(37021-34-4)
• EPA Substance Registry System: 1,2,2,2-TETRACHLORO-1-FLUOROETHYL METHYL ETHER(37021-34-4)

Safety Data

• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 37021-34-4(Hazardous Substances Data)

Usage

General Description

1,2,2,2-Tetrachloro-1-fluoroethyl methyl ether is a chemical compound with the molecular formula C3H4Cl4F. It is a colorless, flammable liquid that is primarily used as a solvent and intermediate in the production of other chemicals. 1,2,2,2-TETRACHLORO-1-FLUOROETHYL METHYL ETHER is considered hazardous and is classified as a toxic and carcinogenic substance. It can pose serious health risks if inhaled, ingested, or in contact with skin and eyes, and it may cause respiratory and skin irritation, as well as damage to the liver and kidneys. Exposure to this chemical should be avoided, and proper safety precautions must be taken when handling or working with it.

InChI:InChI=1/C3H3Cl4FO/c1-9-3(7,8)2(4,5)6/h1H3

Upstream product

• 76-38-0 methoxyflurane 
• 433-50-1 2,2-Dichloro-1-fluorovinyl methyl ether 

Downstream Products

• 661-75-6 2,2,2-Trichloro-1,1-difluoroethyl methyl ether 
• 74-87-3 methylene chloride 
• 593-53-3 Methyl fluoride 
• 354-13-2 trichloroacetyl fluoride 
• 76-02-8 trifluoroacetyl chloride 

Relevant articles and documents

Acid fluorides and 1,1-difluoroethyl methyl ethers as new organic sources of fluoride for antimony pentachloride-catalyzed halogen-exchange reactions

1,1-Difluoroethyl methyl ethers such as the commercial veterinary anesthetic methoxyflurane (2,2-dichoro-1,1-difluoroethyl methyl ether, 6) decompose in the presence of a catalytic amount of antimony pentachloride. The rate of decomposition is dependent upon the number and position of halogen atoms in the ether: a high degree of halogenation at the methyl group or at the 2-position of the ethyl group makes the ether less prone to decomposition. The decomposition products are acid fluorides and halogenated methanes. The fate of the antimony pentachloride is conversion to a fluorochloroantimony species which can be used in situ to selectively fluorinate a polychlorinated substrate. Thus, 1,2,2,2-tetrachloro-1-fluoroethyl methyl ether (1) is converted cleanly to the anesthetic compound 2,2,2-trichloro-1,1-difluoroethyl methyl ether (2) using 6 as the fluoride source, exploiting the difference in stability of 2 and 6 to the pentavalent antimony species. It is also demonstrated that the acid fluorides obtained from decomposition of the 1,1-difluoroethyl methyl ethers are fluoride sources for halex reactions.