37033-97-9Relevant articles and documents
Pyrenedione-Catalyzed α-Olefination of Nitriles under Visible-Light Photoredox Conditions
Bains, Amreen K.,Ankit, Yadav,Adhikari, Debashis
supporting information, p. 2019 - 2023 (2021/04/05)
Herein, we report a combination of pyrenedione (PD) and KOtBu to achieve facile alcohol dehydrogenation under visible-light excitation, where aerobic oxygen is utilized as the terminal oxidant. The resulting carbonyl compound can be easily converted to vinyl nitriles in a single-pot reaction, at 60 °C in 6-8 h. This environmentally benign, organocatalytic approach has distinct advantages over transition-metal-catalyzed α-olefination of nitriles, which often operate at a significantly higher temperature for an extended reaction time.
Antiproliferative activity and mode of action analysis of novel amino and amido substituted phenantrene and naphtho[2,1-b]thiophene derivatives
Gupta, Chhedi Lal,Hranjec, Marijana,Juri?i?, ?tefica,Klobu?ar, Marko,Malod-Dognin, No?l,Paveli?, Sandra Kraljevi?,Perin, Nata?a,Pr?ulj, Nata?a,Rep, Valentina,Selgrad, Danijel,Sovi?, Irena
, (2019/11/28)
Herein we present and describe the design and synthesis of novel phenantrene derivatives substituted with either amino or amido side chains and their biological activity. Antiproliferative activities were assessed in vitro on a panel of human cancer cell lines. Tested compounds showed moderate activity against cancer cells in comparison with 5-fluorouracile. Among all tested compounds, some compounds substituted with cyano groups showed a pronounced and selective activity in the nanomolar range of inhibitory concentrations against HeLa and HepG2. The strongest selective activity against HeLa cells was observed for acrylonitriles 8 and 11 and their cyclic analogues 15 and 17 substituted with two cyano groups with a corresponding IC50 = 0.33, 0.21, 0.65 and 0.45 μM, respectively. Compounds 11 showed the most pronounced selectivity being almost non cytotoxic to normal fibroblasts. Additionally, mode of biological action analysis was performed in silico and in vitro by Western blot analysis of HIF-1-α relative expression for compounds 8 and 11.
Benzannelated Analogs of Phenanthro- and thiophene: Synthesis and Structural Characterization by Two-Dimensional NMR and X-Ray Techniques
Stuart, John G.,Quast, Michael J.,Martin, Gary E.,Lynch, Vincent M.,Simonsen, Stanley H.,et al.
, p. 1215 - 1234 (2007/10/02)
Syntheses of benzophenanthrothiophene, benzophenanthrothiophene and their 1-methyl analogs are reported as potential constituents of solvent refined coal liquids and for mutagenicity testing.The attempted synthesis of the 13-methyl